Results 91 to 100 of about 24,058 (175)

A Natural Resource‐Based View of Circular Economy Practices in the Pharmaceutical Industry

Business Strategy and the Environment, Volume 35, Issue 3, Page 4587-4605, March 2026.
ABSTRACT Pharmaceutical industry is facing escalating environmental sustainability issues including gaseous emissions, waste generation, and excessive consumption of energy and non‐renewable materials. Nevertheless, the adoption of sustainable business models such as the circular economy (CE) is still in its infancy in this sector due to complex ...
Amna Farrukh, Muhammad Sohaib Sajjad
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

The Effect of Sertraline on Hemodynamic Parameters and Nitric Oxide Production in Isolated Rat Hearts Subjected to Ischemia and Reperfusion

Journal of Experimental Pharmacology, 2019
Bartosz Grotthus, Adam Szeląg Department of Pharmacology, Wroclaw Medical University, Wroclaw, PolandCorrespondence: Bartosz GrotthusDepartment of Pharmacology, Wroclaw Medical University, Ul. Jana Mikulicza-Radeckiego 2, Wrocław 50-345, PolandTel +48 71
Grotthus B, Szeląg A
doaj  

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids

Translational Psychiatry
In addition to modulating serotonin transport, selective serotonin reuptake inhibitors (SSRIs) have multiple other mechanisms that may contribute to clinical effects, and some of these latter actions prompt repurposing of SSRIs for non-psychiatric ...
Yukitoshi Izumi, Angela M. Reiersen, Eric J. Lenze, Steven J. Mennerick, Charles F. Zorumski   +4 more
doaj   +1 more source

Effectiveness of Pleasure Perception Training Group Therapy on Adolescents With Depression and Analysis of Factors Associated With Non‐Suicidal Self‐Injurious Behaviors

International Journal of Methods in Psychiatric Research, Volume 35, Issue 1, March 2026.
ABSTRACT Objective This study is designed to explore the effectiveness of pleasure perception training group (PPTG) therapy on adolescents with depression and the factors that influence the presence of non‐suicidal self‐injurious behavior (NSSI). Methods A hundred and twenty adolescent depression patients were randomly assigned to either a control ...
Xinliang Chen, Lingkai Yang, Tingting Jin, Jie Liu, Feifei Zhao, Xiang Li, Ming Zhao, Liwei Zang   +7 more
wiley   +1 more source

Psychiatric Safety of Tirzepatide in People With Obesity and No Known Major Psychopathology: A Post Hoc Analysis of SURMOUNT

Obesity, Volume 34, Issue 3, Page 565-578, March 2026.
ABSTRACT Objective This post hoc analysis assessed psychiatric changes with tirzepatide in adults with obesity, without known major psychopathology, from SURMOUNT‐1, SURMOUNT‐2, and SURMOUNT‐3. Methods In participants (N = 4056) treated with tirzepatide (5/10/15 mg or maximum tolerated dose 10/15 mg) versus placebo, depressive symptoms and suicidal ...
Thomas A. Wadden, Maria A. Oquendo, Robert F. Kushner, Dachuang Cao, Chrisanthi A. Karanikas, Afton Kechter, Madhumita A. Murphy   +6 more
wiley   +1 more source

Improvement in avoidance in major depressive disorder: A 10‐month prospective study of depressive symptoms and personality traits

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim Avoidance is a key maintaining factor in major depressive disorder (MDD); however, longitudinal evidence remains limited, and its association with personality traits is not fully understood. This study aimed to (1) examine the longitudinal associations among avoidance, depressive symptoms, and rumination and (2) explore the relationship ...
Ryotaro Higuchi, Atsuo Nakagawa, Dai Mitsuda, Waka Nogami, Mizuki Amano, Sakae Ihara, Aoi Ito, Sachiko Noda, Nariko Katayama, Hiroki Kocha   +9 more
wiley   +1 more source

Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to best practices in clinical trial protocols. Integrated systems containing RAG and large language model (LLM) components were employed to evaluate drug information and
Shreyas Waikar, Amruta Gajanan Bhat, Murali Ramanathan   +2 more
wiley   +1 more source

Real‐World Pharmacological Management of Alcohol Dependence in a Nepalese Rehabilitation Center: Prospective Cohort Study

Public Health Challenges, Volume 5, Issue 1, March 2026.
This prospective cohort study demonstrates that structured, evidence‐informed pharmacological management significantly reduced alcohol withdrawal severity and improved liver enzyme profiles among alcohol dependence patients in a Nepalese rehabilitation center, supporting the implementation of standardized treatment protocols in resource‐limited ...
Sanjay Singh, Nirmal Raj Marasine, Sabina Sankhi, Kabita Bhandari, Gajendra Bahadur Bhuju   +4 more
wiley   +1 more source