Results 91 to 100 of about 52,947 (295)

Supplementary Figure 3 from The Antidepressant Sertraline Inhibits Translation Initiation by Curtailing Mammalian Target of Rapamycin Signaling [PDF]

, 2023
Chen‐Ju Lin, Françis Robert, Rami Sukarieh, Stephen W. Michnick, Jerry Pelletier   +4 more
openalex   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

Scientific Reports, 2018
Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for ...
J. Weeks, W. M. Roberts, Caitlyn Leasure, Brian M. Suzuki, Kristin J. Robinson, Heather N Currey, P. Wangchuk, R. Eichenberger, Aleen D. Saxton, T. Bird, B. Kraemer, A. Loukas, J. Hawdon, C. Caffrey, Nicole F. Liachko   +14 more
semanticscholar   +1 more source

84 Using Opportunistic Sampling and Remnant Blood Samples to Develop Pediatric Pharmacokinetic Models to Inform Antidepressant Dosing

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Developing pharmacokinetic (PK) models to guide selective serotonin reuptake inhibitor (SSRI) dosing in youth is costly, time-intensive, and requires large numbers of participants. We evaluated the use of remnant blood samples from SSRI-
Jeffrey R. Strawn, Ethan A. Poweleit, Zachary L. Taylor, Tomoyuki Mizuno, Samuel Vaughn, Zeruesenay Desta, Stephani Stancil, Laura B. Ramsey   +7 more
doaj   +1 more source

Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. [PDF]

, 2011
BACKGROUND: Stroke is the major cause of adult disability. Selective serotonin reuptake inhibitors (SSRIs) have been used for many years to manage depression.
Anne Claxton, Cheng-Fang Hsieh, Gillian E Mead, Graeme J Hankey, Mansur A Kutlubaev, Maree L Hackett, Rebecca Lee   +6 more
core   +1 more source

Indirect effects of Seeking Safety plus sertraline on alcohol use: The mediating role of reductions in posttraumatic stress disorder symptom severity

Journal of Traumatic Stress, EarlyView.
Abstract Posttraumatic stress disorder (PTSD) symptoms and alcohol use frequently co‐occur and are mutually reinforcing. Few studies have examined how changes in PTSD severity influence subsequent changes in alcohol use, particularly in the context of comorbidity treatments. This secondary analysis utilized data from a clinical trial comparing 12 weeks
Lesia M. Ruglass, Jordan A. Gette, Antonio A. Morgan‐López, Ai Ye, Kathryn Z. Smith, Skye Fitzpatrick, Teresa López‐Castro, Lissette M. Saavedra, Sonya B. Norman, Therese K. Killeen, Sudie E. Back, Denise A. Hien   +11 more
wiley   +1 more source

State Prescription Drug Price Web Sites: How Useful to Consumers? [PDF]

, 2008
Compares ten sites and identifies key limitations due to data omissions, gaps between insured and uninsured consumers, and varied program implementation.
Catherine G. Corey, Ha T. Tu
core  

Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative

Macromolecular Materials and Engineering, EarlyView.
Chewable softgels are a patient‐preferred alternative to conventional oral forms, offering pleasant taste, fast onset, and suitability for children or patients with swallowing difficulties. However, they present relevant challenges in their formulation: the shell must balance chewability, machinability, and stability, while the fill must mask the ...
Almudena Naharros‐Molinero, María Ángela Caballo‐González, Francisco Javier de la Mata, Sandra García‐Gallego   +3 more
wiley   +1 more source

Sertraline in symptomatic chronic breathlessness: a double blind, randomised trial

European Respiratory Journal, 2018
Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated? 223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2)
D. Currow, M. Ekström, S. Louw, Julie Hill, B. Fazekas, K. Clark, P. Davidson, C. McDonald, D. Sajkov, N. McCaffrey, M. Doogue, A. Abernethy, M. Agar   +12 more
semanticscholar   +1 more source

Effect of sertraline on proliferation and neurogenic differentiation of human adipose-derived stem cells

Advanced Biomedical Research, 2014
Background: Antidepressant drugs are commonly employed for anxiety and mood disorders. Sertraline is extensively used as antidepressant in clinic. In addition, adipose tissue represents an abundant and accessible source of adult stem cells with the ...
Shahnaz Razavi, Maliheh Jahromi, Nushin Amirpour, Zahra Khosravizadeh   +3 more
doaj   +1 more source