Results 101 to 110 of about 1,176,128 (312)

Liraglutide and renal outcomes in type 2 diabetes [PDF]

, 2017
In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks ...
Brown-Frandsen, Kirstine, Buse, John B., Mann, Johannes F. E, Maranghi, M., Marso, Steven P, Poulter, Neil R, Rasmussen, Søren, Tornøe, Karen, Zinman, Bernard, Ørsted, David D   +9 more
core   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Serum albumin and hospitalization among pediatric patients with end-stage renal disease who started dialysis therapy. [PDF]

, 2019
BackgroundHypoalbuminemia is a strong predictor of hospitalization and mortality among adult dialysis patients. However, data are scant on the association between serum albumin and hospitalization among children new to dialysis.MethodsIn a retrospective ...
Brunelli, Steven M, Jernigan, Stephanie M, Kalantar-Zadeh, Kamyar, Langman, Craig B, Laster, Marciana, Obi, Yoshitsugu, Okuda, Yusuke, Rhee, Connie, Salusky, Isidro B, Schreiber, Martin J, Streja, Elani, Tentori, Francesca   +11 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Serum albumin level in a sample of Egyptian patients with major depressive and bipolar disorders; a case control comparative study

Middle East Current Psychiatry
Background Inflammation plays a significant role in the development of major depression and bipolar disorders. This research examines albumin as a potential inflammatory biomarker in these conditions to detect its involvement and explore the connection ...
Maha Mohamed Sayed, Maha Mohamed El Gaafary, Mona Mahmoud Ebrahim Elsheikh, Sohayla Samy Hamed, Rahma Mohamed Abdelaziz Mohamed, Mariam Yehia Mohamed Aboutaleb   +5 more
doaj   +1 more source

Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature

Nutrition Journal, 2010
Background There are several methods of assessing nutritional status in cancer of which serum albumin is one of the most commonly used. In recent years, the role of malnutrition as a predictor of survival in cancer has received considerable attention. As
Lis Christopher G, Gupta Digant
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Joint Effect of Dietary Protein Intake and Inflammation on Serum Albumin Level in Long-Term Maintenance Hemodialysis (MHD) Patients

Kidney Research and Clinical Practice, 2012
Serum albumin is one of the strongest mortality-predictors in MHD patients. Yet, the degree to which serum albumin represents dietary protein intake or inflammation is not clear.
Youngmee Kim, Miklos Z Molnar, Manoch Rattanasompatikul, Parta Hatamizadeh, Debbie Benner, Joel D Kopple, Csaba P Kovesdy, Kamyar Kalantar-Zadeh   +7 more
doaj   +1 more source