Results 81 to 90 of about 1,781,612 (307)

Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women

BMC Infectious Diseases, 2006
Background Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response.
Bankson Daniel D, Wener Mark H, Overbaugh Julie, Baeten Jared M, Drain Paul K, Lavreys Ludo, Mandaliya Kishorchandra, Ndinya-Achola Jeckoniah O, McClelland R Scott   +8 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Quantification of the difference between pre-dialysis and post-dialysis serum albumin measurement and its relationship to intra-dialytic weight gain

Kidney Research and Clinical Practice, 2012
Haemodialysis patients may have low albumin levels due to a cascade of factors, including inflammation and reduced dietary intake. Albumin is commonly used in clinical settings by dieticians as part of a comprehensive nutritional assessment.
Alwyn Todd, Anthony Meade, Robert Carroll, Kerin O’ Dea, Stephen Mac Donald   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Preoperative low serum albumin increases the rate of perioperative blood transfusion in patients undergoing total joint arthroplasty: propensity score matching

BMC Musculoskeletal Disorders
Background To investigate the relationship between preoperative low serum albumin and perioperative blood transfusion in patients undergoing total joint arthroplasty (TJA). Methods We enrolled 2,772 TJA patients from our hospital between January 1, 2017,
Shenglian Xu, Xiaojuan Xiong, Ting Li, Peng Hu, Qingxiang Mao   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Associations of weight loss, low serum albumin, and their combination with mortality risk in older adults receiving home medical care

BMC Research Notes
Objective This study aimed to examine the associations of weight loss, low serum albumin levels, and their combination with 2-year mortality risk in older adults receiving home medical care.
Tomoko Yano, Naoko Murakami, Yuka Fukata, Chika Nakamura, Chihiro Anzai, Yumiko Nako, Eriko Koujiya, Toshinori Nakamura, Atsushi Hirotani, Toshio Fukuda, Michio Tamatani, Yoshinari Okuda, Masashi Ikushima, Yoshichika Baba, Masahiro Nagano, Yukio Nakamura, Taizo Wada, Yuya Akagi, Kayo Godai, Michiko Kido, Mai Kabayama, Hiromi Rakugi, Kei Kamide   +22 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Serum uric acid and albumin levels and estimated glomerular filtration rate: Oxidative stress considerations

, 2012
Uric acid has both antioxidant and oxidant properties, is excreted by the kidney and is associated with development of kidney disease. Albumin, another antioxidant is also excreted by the kidney in some renal diseases.
Ruven, Henk, Nielsen, Sharon, Kalle, Wouter, Butkowski, Eugene, Nwose, Uba, Bwititi, Phillip, Richards, Ross   +6 more
core   +1 more source