Results 41 to 50 of about 1,897,479 (242)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum [PDF]

, 2018
Aim:Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was ...
Eren Pek, Beyazit, Fatma, Turkon, Hakan, Fatma Beyazıt, Hakan Türkön, Pek, Eren   +5 more
core   +1 more source

Choice of assay affects serum albumin measurements in HIV patients: A comparison of bromocresol green and bromocresol purple dye binding methods

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Background: Dye-binding assays – bromocresol green (BCG) and bromocresol purple (BCP) –are widely used for serum albumin measurement. Differences between the results reported by these assays can have important clinical implications.
Amrita Parmar, Deeptika Agarwal, Tapan Kumar Saha, Babu Lal Somani, Pratibha Misra   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Correlation between Serum Albumin Level and Severity of Acute Ischemic Stroke : A Cross-Sectional Study

Journal of Nepal Medical Association
Introduction: Stroke is a leading cause of disability with devastating consequences. Serum albumin has emerged as a significant prognostic marker in various conditions, including stroke.
Binod Pantha, Milan Khadka, Lochan Karki, Parimal Koirala   +3 more
doaj   +1 more source

Early predictors of neonatal hyperbilirubinemia in full term newborn

Pediatrics and Neonatology, 2019
Background: Reliable predictive markers enabling physicians to identify which newborns will develop significant hyperbilirubinemia have become mandatory for prevention of severe hyperbilirunemia.
May Ahmed Khairy, Walaa Alsharany Abuelhamd, Ismail Mohamed Elhawary, Ahmed Said Mahmoud Nabayel   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Assessment of the Predictive Value of Preoperative Serum Albumin and Postoperative Albumin Drop (ΔAlb) for Complications after Pancreas Surgery: A Single-Center Cross-Sectional Study [PDF]

, 2023
Background: Serum albumin has been shown to be predictive of complications after various gastrointestinal operations. The present study aimed to assess whether preoperative serum albumin and serum albumin drop on postoperative day 1 are associated with ...
Sérgio Gaspar-Figueiredo, Ismail Labgaa, Gaëtan-Romain Joliat, Demartines, Nicolas, Gaspar-Figueiredo, Sérgio, Labgaa, Ismail, Markus Schäfer, Joliat, Gaëtan-Romain, Nicolas Demartines, Schäfer, Markus, Joliat, G.R., Schäfer, M., Labgaa, I., Demartines, N., Gaspar-Figueiredo, S.   +14 more
core   +2 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Hubungan Kadar Albumin Serum dengan Eritropoetin Serum pada Sindrom Nefrotik Anak Resisten Steroid

Sari Pediatri, 2016
Latar belakang. Pasien sindrom nefrotik resisten steroid mengalami hipoeritropoetinemia akibat kehilangan eritropoetin melalui urin dan gangguan pembentukan eritropoetin oleh ginjal.
Endah Purnawati, Dany Hilmanto, Adi Utomo Suardi   +2 more
doaj   +1 more source