Results 31 to 40 of about 1,897,479 (242)

The Minimal Effect of Linker Length for Fatty Acid Conjugation to a Small Protein on the Serum Half-Life Extension

Biomedicines, 2020
Conjugation of serum albumin or one of its ligands (such as fatty acid) has been an effective strategy to prolong the serum half-lives of drugs via neonatal Fc receptor (FcRn)–mediated recycling of albumin.
Jinhwan Cho, Junyong Park, Giyoong Tae, Mi Sun Jin, Inchan Kwon   +4 more
doaj   +1 more source

Helicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China

Journal of Inflammation Research, 2022
He Liu,* Yan Qin,* Jie Yang, Guoxiu Huang, Xiaoying Wei, Lulu Wang, Wei Li Department of Health Management, The People’s Hospital of Guangxi Zhuang Autonomous Region & Research Center of Health Management, Guangxi Academy of Medical Sciences ...
Liu H, Qin Y, Yang J, Huang G, Wei X, Wang L, Li W   +6 more
doaj  

Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease [PDF]

, 2010
Background: there is accumulating evidence that oxidative stress plays an important role in the pathophysiology of chronic obstructive pulmonary disease (COPD).
Treasure, Tom, Hackett Tillie L, Warner Jane A, Wan Tan, Tan Wan, Lu Zheng, Tom Treasure, Hackett, Tillie-Louise, Scarci Marco, Treasure Tom, Zheng Lu, Marco Scarci, Jane A Warner, Warner, Jane A., Tillie L Hackett, Scarci, Marco, Zheng, Lu, Tan, Wan   +17 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Ischemia-modified albumin (IMA) should be interpreted with caution in patients with low serum albumin concentrations

, 2006
Objective: Ischemia-modified albumin (IMA®) is a novel marker for assessing cardiac ischaemia. We assessed the relationship between total albumin concentrations and IMA in serum to investigate whether interpretation of IMA was albumin-dependent ...
Crompton, L., Collinson, P.O., Gaze, D.C.   +2 more
core   +1 more source

Potential value of serum prealbumin and serum albumin in the identification of postoperative delirium in patients undergoing knee/hip replacement: an observational study and internal validation study

Frontiers in Neurology
BackgroundPostoperative delirium (POD) is a common postoperative neurological complication that can lead to a variety of postoperative complications. At present, the pathogenesis of POD is unclear.
Bin Wang, Yan Xin, Xinhui Tang, Fei Wang, Shuhui Hua, Yunchao Yang, Shanling Xu, Hongyan Gong, Rui Dong, Yanan Lin, Chuan Li, Xu Lin, Yanlin Bi   +12 more
doaj   +1 more source

Single-center analysis of the inappropriate use of human albumin and nutritional support in hospitalized patients with hypoproteinemia in China

Journal of International Medical Research, 2021
Background This study used single-center analysis of human serum albumin clinical usage and enteral-parenteral nutritional support to establish clinical application standards for the rational use of human serum albumin.
Jin Zhang, ZheTao Zhang, TianLu Shi
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Relationships among Serum Glucose, Albumin Concentrations and Carotid Atherosclerosis in Men with Spinal Cord Injury

, 2010
Limited information is available that examines the interrelationships between glucose tolerance, serum albumin, subclinical inflammation, and carotid atherosclerosis (CA) in patients with spinal cord injury (SCI).
WANG, YEN-HO;CHEN, SSU-YUAN;WANG, TZUNG -DAU;HWANG, BAO-SHOW;HUANG, TIEN-SHANG;SU, TA-CHEN, 王顏和;陳思遠;王宗道;黃寶秀;黃天祥;蘇大成   +1 more
core   +1 more source

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

The International Journal of Biological Markers, 2017
Background Serum albumin levels have been shown to have prognostic significance in hepatocellular carcinoma (HCC), as part of an inflammatory index. The aim of this study was to examine the possible relationship of serum albumin levels to parameters of ...
Brian I. Carr MD, FRCP, PhD, Vito Guerra
doaj   +1 more source