Results 71 to 80 of about 1,146,310 (293)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Estimation of serum albumin levels associated with chronic periodontitis in elderly subjects - A cross sectional study

SRM Journal of Research in Dental Sciences, 2012
Aim: The present study was conducted to evaluate the association between serum albumin and chronic periodontitis in elderly individuals. Methodology: Sixty systemically healthy subjects in the age group of fifty and above were included in the study ...
A V Saravanan, R Mythili Swaminathan, K H Panishankar, Pradeep Kumar   +3 more
doaj  

Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women

BMC Infectious Diseases, 2006
Background Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response.
Bankson Daniel D, Wener Mark H, Overbaugh Julie, Baeten Jared M, Drain Paul K, Lavreys Ludo, Mandaliya Kishorchandra, Ndinya-Achola Jeckoniah O, McClelland R Scott   +8 more
doaj   +1 more source

Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia [PDF]

, 2017
BACKGROUND: Chronic kidney disease (CKD) is a common comorbidity in cats with hypercalcemia, but whether CKD is a risk factor for hypercalcemia is unclear.
Abdi, Andress, Barber, Barber, Barber, Berend, Berry, Bertazzolo, Bienzle, Blaine, Block, Burnell, Bushinsky, Chakrabarti, Cole, Costanzo, DiBartola, Elliott, Elliott, Eren, Finch, Flanders, Fogh-Andersen, Gal, Gauci, Geddes, Geddes, He, Jackson, Kelly, Kogika, Kovesdy, Kurz, Lemann, Levi, Levi, Lulich, Malatesha, Marino, Marone, McLeland, Meghji, Meuten, Midkiff, Must, Payne, Peacock, Picolos, Pieper, Piraino, Polzin, Rafferty, Savary, Schenck, Schenck, Schenck, Schenck, Schenck, Schenck, Schenck, Shanahan, Shipov, Sutton, Tentori, Williams, Yamada, Yang   +66 more
core   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Optimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]

, 2011
Peer reviewedPublisher ...
Campbell, Fiona Margaret, Carpintero, Rakel, Eckersall, P. David, Gruys, Erik, Heegaard, Peter M. H., Lampreave, Fermin, Piñeiro, Matilde, Skall Sorensen, Nanna, Stockmarr, Anders, Toussaint, Mathilda J.M.   +9 more
core   +4 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Effects of serum proteins on corrosion behavior of ISO 5832–9 alloy modified by titania coatings [PDF]

, 2014
Stainless steel ISO 5832–9 type is often used to perform implants which operate in protein-containing physiological environments. The interaction between proteins and surface of the implant may affect its corrosive properties.
Andrzej Leniart, B Feng, Barbara Burnat, C Liu, CC Dupont-Gillain, D Sun, D Velten, D Wang, FH Jones, G Rondelli, H Huang, JE Ellingsen, K Merrit, MLCA Afonso, P Galliano, RL Williams, S Karimi, S Karimi, S Omanovic, SH Ahn, T Kopac, Tadeusz Blaszczyk, TO Collier, YS Hedberg   +23 more
core   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source