Results 91 to 100 of about 1,441,088 (304)

Prevalence of Vitamin D Deficiency Among Children (0-12 Years) in Secondary Care Hospital: A Cross-Sectional Study Over One Year Period

Journal of Pharmacy and Bioallied Sciences
Objective: This study was carried out to assess the prevalence of vitamin D deficiency and insufficiency in study group of children aged 0 to 12 years.
Yousef Alrohaimi, Badar A Almuqhem
doaj   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Comparison of serum calcium, magnesium, phosphate, alkaline phosphatase, and vitamin D levels in children consuming reverse osmosis, non reverse osmosis, and high fluoride drinking water

Scientific Reports
Water is vital for the human body. Due to concerns over tap water, preference for taste, and convenience, there has been increased consumption of reverse osmosis (RO) water.
H. M. Thippeswamy , Raghavendra Shanbhog, M. Nanditha Kumar, S. N. Prashanth, P. Smitha   +4 more
doaj   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Multiple fractures, pain, and severe disability in a patient with adult-onset hypophosphatasia

Bone Reports, 2016
Hypophosphatasia (HPP) is a rare, inherited metabolic bone disease resulting from mutations in the gene encoding tissue non-specific alkaline phosphatase.
Neil A. Braunstein
doaj   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Correlation between serum levels of uric acid with bone turnover markers in postmenopausal women

Iranian South Medical Journal, 2015
Background: There is accumulation evidence regarding the protective role of higher serum uric acid in bone loss and osteoprotic fractures. This effect may arise from its antioxidant properties.
Fariba Karimi, Firooze Mozhde, Hussain Darabi, Mohammadreza Kalantar hormozi, Samad Akbarzadeh, Afshin Ostovar, Majid Assadi, Katayon Vahdat, Iraj nabipour   +8 more
doaj  

Sample storage and fasting times affect blood serum and plasma components in fasted and non-fasted broiler chickens

Journal of Applied Poultry Research
Summary: We determined the impacts of blood fraction, fasting and samples storage times on the total protein, albumin, globulin, uric acid, creatinine concentrations, and alkaline phosphatase activity in 70 45-d-old male Cobb 500® broiler chickens. Blood
Clauber Polese, Lucas Wachholz, Cinthia Eyng, Leandro Dalcin Castilha, Jansller Luiz Genova, Rayanne Andrade Nunes, Nilton Rohloff, Jr., Paulo Cesar Pozza, Lidiane Ines Datsch, Arele Arlindo Calderano, José Geraldo de Vargas, Jr., Vaneila Daniele Lenhardt Savaris, Ricardo Vianna Nunes   +12 more
doaj   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source