Results 71 to 80 of about 234,032 (301)
Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2018 Background An association between antiepileptic drugs, low bone mineral density (BMD), fractures, and abnormalities in bone metabolism has been suggested for a longer period, although conclusive evidence has not been reported.
Ebtesam Mohamed Fahmy +4 more
doaj +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Osteocalcin and bone-specific alkaline phosphatase in Sickle cell haemoglobinopathies
, 2010 Osteocalcin or bone gamma-carboxyglutamic acid (gla) protein and Bone-specific alkaline phosphatase (b-AP) total protein levels were evaluated as indicators of bone turnover in twenty patients with sickle cell haemoglobinopathies and in twenty normal ...
Azinge, E.C, Bolarin, D.M
core +1 more source
Advanced Science, EarlyView.THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
Sudan Journal of Medical Sciences, 2019 Background: Psoriasis is an autoimmune inflammatory, chronic, and relapsing disease of the skin, which can also present with severe joint inflammation and deformity.
Suad HH +3 more
doaj +1 more source
, 2012 AIM: Osteopaenia commonly occurs in preterm infants; however , its diagnosis is often delayed when based on radiological findings. The aim of this study was to examine whether serial measurements of bone turnover markers are useful for early prediction ...
HUNG, YI-LI;CHEN, PAU-CHUNG;JENG, SUH-FANG;HSIEH, CHIA-JUNG;PENG, STEVEN SHINN-FORNG;YEN, RUOH- FANG;CHOU, HUNG-CHIEH;CHEN, CHIEN-YI;TSAO, PO- NIEN;HSIEH, WU-SHIUN +1 more
core
THE RELATIONSHIP OF DIETARY FACTORS TO RAT SERUM ALKALINE PHOSPHATASE
, 1952 Weanling rats were fed dietary concentrations of 0%, 5%, 10%, 30%, and 91% casein. Complete absence of dietary protein resulted in death of the young animals within five weeks.
Neil B. Madsen +3 more
core +1 more source
Advanced Science, EarlyView.This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He +10 more
wiley +1 more source
Advanced Science, EarlyView.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source