Results 21 to 30 of about 313,077 (257)

The relationship between glucose metabolism, metabolic syndrome, and bone-specific alkaline phosphatase: a structural equation modelling approach [PDF]

, 2014
PosterINTRODUCTION: Serum alkaline phosphatase plays a role in vascular calcification. It is found in various tissues, whereas bone-specific alkaline phosphatase (BAP) more specifically reflects mineral metabolism.
Cheung, BMY, Cheung, CL, Lam, KSL, Tan, KCB   +3 more
core  

Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies [PDF]

, 1992
We examined the roles of the extracellular domains of a gap junction protein and a cell adhesion molecule in gap junction and adherens junction formation by altering cell interactions with antibody Fab fragments.
Johnson, Ross G., Laird, Dale W., Meyer, Rita A., Revel, Jean-Paul   +3 more
core   +2 more sources

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source

The effect of 12 weeks regular physical activity and vitamin E in the treatment of non-alcoholic steatohepatitis: A pilot study [PDF]

, 2015
Background: Despite the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), there was no treatment has been proven to be effective in these common diseases.
Eslami, L., Isazadehfar, K., Karami, M., Eslami, L., Rahmani-nia, F., Nakhostinroohi, B.   +5 more
core   +7 more sources

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations [PDF]

, 2010
<b>Background</b>: Acute phase proteins (APPS) include haptoglobin (Hp), C-reactive protein (CRP) and serum amyloid A (SAA). Increased Hp concentrations may be induced by endogenous or exogenous glucocorticoids in dogs. <b>Objectives&
Angles, Behrend, Braddock, Caldin, Cerón, Child, Dohoo, Dunn, Eckersall, Eckersall, Feldman, Fraser, Greiner, Harvey, Herrtage, Kaplan, Kobelt, Kushner, Ling, Martínez-Subiela, Martínez-Subiela, McGrotty, McGrotty, Meijer, Mischke, Neiger, Oliver, Onishi, Perez-Alenza, Ruckstuhl, Siebert-Ruckstuhl, Solter, Tecles, Teske, Thomson, Vaessen, Wilson   +36 more
core   +1 more source

Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes

Advanced Functional Materials, EarlyView.
Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen, Andreas B. Pedersen, Mireia Casanovas Montasell, Søren Moesgaard, Anja Bille Bohn, Alexander N. Zelikin   +5 more
wiley   +1 more source

Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration

Advanced Functional Materials, EarlyView.
A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo, Zaijin Tao, Zhenzhen Dai, Yinghua Gao, Chengzhen Chu, Cunyi Fan, Shen Liu, Xin Ma, Fangchun Jin, Zhengwei You, Jia Jiang   +10 more
wiley   +1 more source

Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]

, 2010
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique, De Bus, Liesbet, Depuydt, Pieter, Libbrecht, Louis, NOLLET, JOKE, Van Vlierberghe, Hans, Vandekerckhove, Linos, Vogelaers, Dirk   +7 more
core   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source