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Serum amyloid A: The “other” inflammatory protein

Current Atherosclerosis Reports, 2006
Inflammation long has been recognized as a hallmark of atherosclerotic lesions, but more recently attention has focused on chronic low-level elevations of specific plasma inflammatory proteins such as C-reactive protein (CRP) and serum amyloid A (SAA), which may not only represent markers of atherosclerosis risk but also participate directly in ...
Kevin D, O'Brien, Alan, Chait
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Serum Amyloid A Protein (SAA) in Colorectal Carcinoma

Clinical Chemistry and Laboratory Medicine, 2001
The changes in serum levels of serum amyloid A protein were studied in 67 patients suffering from colorectal carcinoma and compared to three other major acute phase proteins: C-reactive protein, alpha1-antichymotrypsin and alpha1-acid glycoprotein. Although the presence of colorectal carcinoma caused an increase in serum levels of all the acute phase ...
Šimić, Diana   +3 more
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Serum Amyloid A Protein in Familial Mediterranean Fever

Annals of Internal Medicine, 1985
Excerpt Amyloid a protein is the subunit of amyloid fibrils that occurs in the forms of amyloidosis commonest in humans and ubiquitous in animals (1, 2).
A, Knecht, F C, de Beer, M, Pras
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Serum Amyloid A Protein in Acute Myocardial Infarction

Acta Medica Scandinavica, 1986
ABSTRACT Tissue injury including myocardial infarction leads to a variety of changes in plasma proteins commonly referred to as “the acute phase response”. In this report the concentrations of serum amyloid A protein (SAA) were measured serially in 6 patients with myocardial infarction and 4 with angina.
G, Marhaug   +5 more
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Serum Amyloid A (SAA) Proteins

2020
As normal constituents of blood serum, the Serum Amyloid A (SAA) proteins are small (104 amino acids in humans) and remarkably well-conserved in mammalian evolution. They are synthesized prominently, but not exclusively, in the liver. Fragments of SAA can associate into insoluble fibrils (called "amyloid") characteristic of "secondary" amyloid disease ...
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SERUM AMYLOID A PROTEIN

Transplantation, 1983
Acute human renal allograft rejection induces a dramatic elevation of serum amyloid A protein (SAA). To evaluate the clinical significance of this finding we monitored 31 consecutive recipients of cadaveric renal allografts by daily SAA measurements. SAA increased significantly during 37/38 rejection episodes.
C P, Maury   +3 more
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Serum Amyloid A Protein—Current Status

Scandinavian Journal of Rheumatology, 1984
L'amyloide A serique est une reagine sensible de la phase aigue qui reflete l'activite inflammatoire des maladies rhumatismales. Elle est le precurseur de l'amyloide A fibrillaire deposee dans les tissus dans l'amyloidose associee a l'inflammation. Puisque la persistance de taux seriques eleves correle avec la progression rapide de la maladie et peut ...
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The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

Immunology Today, 1994
Following an acute phase stimulus, such as infection or physical injury, many liver-derived plasma proteins are increased in concentration. These provide enhanced protection against invading micro-organisms, limit tissue damage and promote a rapid return to homeostasis.
D M, Steel, A S, Whitehead
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Serum Amyloid A (SAA) Protein — Interaction with Itself and Serum Albumin

The Journal of Immunology, 1977
Abstract Serum amyloid A (SAA) protein is a 12,000 dalton protein that exists in serum under physiologic conditions as an 85,000 dalton complex and under certain conditions, as a 170,000 dalton component. To study the reason for this finding, the behavior of 125I-SAA was studied in the presence of cold SAA and several serum proteins. SAA
C J, Rosenthal, E C, Franklin
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Hypothetical structure of human serum amyloid A protein

Amyloid, 2004
The proteins known as serum amyloid A (SAA) play major, but relatively uncharacterized, roles in the acute phase response and are important components of the innate immune system of humans and probably all vertebrates. N-terminal fragments of the inducible isoforms, SAA1 and SAA2, are the major constituents of fibrils formed during secondary or ...
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