Diagnostic accuracy of intraoperative haptoglobin point-of-care testing in ovarian tumor fluid versus frozen section for epithelial ovarian cancer [PDF]
BMC Research NotesObjective Ovarian cancer is the third most common gynaecological cancer and has the high mortality rates and requires accurate intraoperative. Haptoglobin is an acute-phase protein locally elevated in cancer cells, may serve as a novel diagnostic marker.
Benyamin Rakhmatsyah Titaley +7 more
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Frontiers in Physiology, 2022 Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the penile erection control mechanism and resulting in prolonged penile erection
Pamela da Silva Pereira +8 more
doaj +1 more source
Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women. [PDF]
PLoS ONE, 2009 BackgroundHp(2) alleles of the haptoglobin alpha-chain polymorphism reduce the anti-oxidant properties and increase the pro-inflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin polymorphism might
Francisco Alvarez-Blasco +5 more
doaj +1 more source
Haptoglobin-Conjugated Gold Nanoclusters as a Nanoantibiotic to Combat Bacteremia
Nanomaterials, 2022 Gold nanoclusters have revealed great potential as nanoantibiotics due to their superior chemical and physical characteristics. In this study, a peptide with 83 amino acids derived from haptoglobin was utilized as a surface ligand to synthesize gold ...
Hsiu-Yi Chu +6 more
doaj +1 more source
Scientific Reports, 2021 Recent evidence supports involvement of the acute phase protein haptoglobin in numerous events during mammalian reproduction. The present study represents an in-depth investigation of haptoglobin expression and secretion in the porcine oviduct and uterus,
Francisco A. García-Vázquez +10 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2021 Aim. To study the relationship between the level of haptoglobin and the main indicators of microcirculation (MC) in patients with different phenotypes of chronic heart failure (CHF).Materials and methods.
V. I. Podzolkov +4 more
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Impact of Haptoglobin Gene Polymorphism on Phenotypic Variability in β-thalassemia Patients: Relation to Iron Overload and Oxidative Stress [PDF]
Afro-Egyptian Journal of Infectious and Endemic Diseases, 2023 Background and study aim: Thalassemia syndromes are genetic disorders in globin chain production. There is excessive synthesis of reactive oxygen species in thalassemia which leads to oxidative stress.
Ola Balbaa +3 more
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Haptoglobin release by human adipose tissue in primary culture
Journal of Lipid Research, 2004 Haptoglobin is a putative adiposity marker because its concentration in blood is increased in obese humans. The present studies examined haptoglobin release by explants of adipose tissue in primary culture.
John N. Fain +2 more
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Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. [PDF]
PLoS ONE, 2018 During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
John D Belcher +12 more
doaj +1 more source
Characterization of Haptoglobin Isotype in Milk of Mastitis-Affected Cows
Veterinary Sciences, 2016 Haptoglobin is a major acute phase protein in bovines and reportedly increases in serum and milk whey during mastitis, highlighting its potential as a diagnostic biomarker.
Indu Upadhyaya +4 more
doaj +1 more source