Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection. [PDF]
BACKGROUND: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states.
Andrew M Prentice +52 more
core +15 more sources
Low Level of Haptoglobin in Lupus [PDF]
Haptoglobin levels are measured in systematic lupus erythematosus patients as part of the workup for anemia, with low levels indicating hemolysis. Haptoglobin is an acute phase protein.
Homa Timlin MD, MSc +2 more
doaj +2 more sources
Haptoglobin Genotypes in Nasopharyngeal Carcinoma [PDF]
Aim Haptoglobin polymorphisms are associated with different cancers; however, the occurrence of nasopharyngeal carcinoma (NPC) in relation to haptoglobin polymorphisms has not been reported.
Ching-Chih Lee +8 more
doaj +2 more sources
Haptoglobin-related protein in human plasma correlates to haptoglobin concentrations and phenotypes [PDF]
Haptoglobin-related protein (Hpr) is a plasma protein with high sequence similarity to haptoglobin (Hp). Like Hp, Hpr also binds hemoglobin (Hb) with high affinity, but it does not bind to the Hb-Hp receptor CD163 on macrophages. The Hpr concentration is
Karsten Skjødt (561175) +9 more
core +1 more source
Evaluation of the Extent of Haptoglobin Glycosylation Using Orthogonal Intact-Mass MS Approaches [PDF]
Intact-mass measurements are becoming an increasingly popular in mass spectrometry (MS) based protein characterization, as they allow the entire complement of proteoforms to be evaluated within a relatively short time.
Ian J., Carrick +3 more
core +1 more source
Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations [PDF]
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties.
G. Veres +35 more
core +1 more source
Development of ELISA against milk haptoglobin for diagnosis of subclinical mastitis in goats
The study described the development of a haptoglobin-based diagnostic tool for mastitis in Ettawa crossbreed goats. Fifty eight milk samples were collected from a flock of goats in Yogyakarta, Central Java, Indonesia. All samples were tested for mastitis
Sarasati Windria +4 more
doaj +1 more source
Characterization of Haptoglobin Isotype in Milk of Mastitis-Affected Cows
Haptoglobin is a major acute phase protein in bovines and reportedly increases in serum and milk whey during mastitis, highlighting its potential as a diagnostic biomarker.
Indu Upadhyaya +4 more
doaj +1 more source
Human serum haptoglobin is toxic to Plasmodium falciparum in vitro. [PDF]
Innate immune responses are important in the control of malaria, particularly in those who have not yet mounted an effective adaptive response. Here we report that the human serum acute phase protein, haptoglobin, is toxic to Plasmodium falciparum ...
Imrie, H +3 more
core +1 more source
Haptoglobin and sickle cell polymorphisms and risk of active trachoma in Gambian children. [PDF]
BACKGROUND: Susceptibility and resistance to trachoma, the leading infectious cause of blindness, have been associated with a range of host genetic factors.
Doherty, CP +52 more
core +1 more source

