Results 11 to 20 of about 41,191 (221)

Low Level of Haptoglobin in Lupus

Journal of Investigative Medicine High Impact Case Reports, 2017
Haptoglobin levels are measured in systematic lupus erythematosus patients as part of the workup for anemia, with low levels indicating hemolysis. Haptoglobin is an acute phase protein.
Homa Timlin MD, MSc, Kirthi Machireddy, Michelle Petri MD, MPH   +2 more
doaj   +2 more sources

Characterization of Haptoglobin Isotype in Milk of Mastitis-Affected Cows

Veterinary Sciences, 2016
Haptoglobin is a major acute phase protein in bovines and reportedly increases in serum and milk whey during mastitis, highlighting its potential as a diagnostic biomarker.
Indu Upadhyaya, Jacob Thanislass, Anitha Veerapandyan, Sharanabasav Badami, Prabhakar X. Antony   +4 more
doaj   +2 more sources

Haptoglobin buffers lipopolysaccharides to delay activation of NFκB

Frontiers in Immunology
It has remained yet unclear which soluble factors regulate the anti-inflammatory macrophage phenotype observed in both homeostasis and tumourigenesis. We show here that haptoglobin, a major serum protein with elusive immunoregulatory properties, binds ...
Laura Zein, Laura Zein, Josina Grossmann, Josina Grossmann, Helena Swoboda, Helena Swoboda, Christina Borgel, Christina Borgel, Bernhard Wilke, Bernhard Wilke, Stephan Awe, Andrea Nist, Thorsten Stiewe, Oliver Stehling, Oliver Stehling, Sven-Andreas Freibert, Sven-Andreas Freibert, Till Adhikary, Till Adhikary, Ho-Ryun Chung   +19 more
doaj   +2 more sources

Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage [PDF]

, 2020
OBJECTIVE: After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and helping its clearance.
Durnford, A, Houlden, H, Gaunt, TR, Gaastra, B, Bonner, S, Walsh, D, Garland, P, Alg, VS, Kazmi, N, Galea, I, Hostettler, IC, Grieve, J, Kitchen, N, Brown, MM, Werring, DJ, Morton, MJ, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study, ., Bulters, DO, Zolnourian, A   +18 more
core   +3 more sources

Haptoglobin-related protein in human plasma correlates to haptoglobin concentrations and phenotypes

, 2022
Haptoglobin-related protein (Hpr) is a plasma protein with high sequence similarity to haptoglobin (Hp). Like Hp, Hpr also binds hemoglobin (Hb) with high affinity, but it does not bind to the Hb-Hp receptor CD163 on macrophages. The Hpr concentration is
Karsten Skjødt (561175), Anna Lahn Sørensen (13838948), Dorle Hennig (13838951), Peter Højrup (455729), Søren Kragh Moestrup (13838954), Maria Boysen Sandberg (9401480), Holger J. Møller (8495121), Maria Kløjgaard Skytthe (13838945), Jonas Heilskov Graversen (13838957), Lars Melholt Rasmussen (7437269)   +9 more
core   +1 more source

STRUCTURAL STUDIES ON HUMAN HAPTOGLOBIN.

, 1966
STRUCTURAL STUDIES ON HUMAN ...
CLAIRE MARY. GERBECK (7982321)
core   +5 more sources

Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations [PDF]

, 2008
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties.
G. Veres, Földi, I., I. R. Korponay-Szabo, M. Udvardy, Veres, Gábor, Udvardy, M., Korponay-Szabó, Ilma Rita, Tumpek, J., L. Toth, Mate, I., Toth, L., Gyetvai, A., Szathmari, E., Altorjay, István, Nemes, E., A. Gyetvai, E. Szathmari, Papp, Mária, Dinya, T., Varvolgyi, C., J. Tumpek, T. Dinya, Z. Barta, E. Nemes, I. Mate, J. Harsfalvi, Hársfalvi, Jolán, C. Varvolgyi, I. Foldi, Lakatos, Péter László, Kapitany, A., P. L. Lakatos, M. Papp, A. Kapitany, I. Altorjay, Barta, Zsolt   +35 more
core   +1 more source

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. [PDF]

PLoS ONE, 2018
During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
John D Belcher, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, Hao Nguyen, Phong Nguyen, Trevor Killeen, Sylvia M Miescher, Nathan Brinkman, Karl A Nath, Clifford J Steer, Gregory M Vercellotti   +12 more
doaj   +1 more source

Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection. [PDF]

, 2007
BACKGROUND: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states.
Andrew M Prentice, Chidi V Nweneka, Kirk A Rockett, Nweneka, Chidi V, Ghattas Hala, Sharon E. Cox, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Kirk A. Rockett, Atkinson, Sarah H., Sharon E Cox, Nweneka, Chidi V., Dominic P. Kwiatkowski, Anthony J.C. Fulford, Atkinson Sarah H., Sarah H. Atkinson, Kwiatkowski, Dominic P., Cox, Sharon E, Prentice, Andrew M., Doherty, Conor, Conor Doherty, Cox, Sharon E., Rockett, Kirk A., Nweneka Chidi V., Anthony J C Fulford, Prentice, Andrew M, Ghattas, Hala, Chidi V. Nweneka, Rockett, Kirk A, Sarah H Atkinson, Fulford, Anthony JC, Cox Sharon E., Fulford, Anthony J.C., Rockett Kirk A., Fulford Anthony J.C., Atkinson, Sarah H, Hala Ghattas, Andrew M. Prentice, Prentice Andrew M., Doherty Conor, Kwiatkowski, Dominic P, Ghattas, Hala, Ph.D.   +41 more
core   +1 more source

Evaluation of serum 25‐hydroxyvitamin D, C‐reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis

Journal of Veterinary Internal Medicine, 2023
Background Serum 25‐hydroxyvitamin (OH)D, C‐reactive protein (CRP), and haptoglobin are useful biomarkers in various infectious diseases and inflammatory disorders in dogs, but their utility in histoplasmosis is unknown.
Betsy Hernandez, Jared A. Jaffey, Leah A. Cohn, Robert C. Backus, Kate KuKanich, Andrew S. Hanzlicek, Valerie J. Parker, Mary E. White, Randy Ringold, Emily Westerback, Leah Freilich, Charlotte Bolch   +11 more
doaj   +1 more source