Results 61 to 70 of about 2,086,143 (299)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Vitamin D supplementation as an adjuvant therapy for patients with T2DM : an 18-month prospective interventional study [PDF]

, 2012
Background Vitamin D deficiency has been associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2 (T2DM).
Al-Othman, Abdulaziz, Osama Moharram, Alokail Majed S, El-Kholie, Emad, Kumar Sudhesh, Sabico, Shaun, Sudhesh Kumar, Sabico Shaun, George P Chrousos, Al-Othman Abdulaziz, Alokail, Majed S., Al-Daghri, Nasser M., Al-Saleh, Yousef, Majed S Alokail, Al-Saleh Yousef, Yousef Al-Saleh, Alkharfy Khalid M, Chrousos, George P., Kumar, Sudhesh, Chrousos George P, Abdulaziz Al-Othman, Emad El-Kholie, Moharram Osama, Nasser M Al-Daghri, Shaun Sabico, El-Kholie Emad, Moharram, Osama, Al-Daghri Nasser M, Alkharfy, Khalid M., Khalid M Alkharfy   +29 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Correlation of Calcium, Magnesium, Uric Acid and Phosphate Levels in Serum, 24-Hour Urine, and Stone Components in Patients with Urolithiasis: A Cross-sectional Study [PDF]

International Journal of Anatomy Radiology and Surgery
Introduction: Urolithiasis is the formation of stony concretions in the bladder or urinary tract. Nearly 10% of the population suffers from urolithiasis, which has a high chance of recurring.
Pranav Prakash, Shikhar Agarwal, Archana Prakash, Anita Sharma, Ashok Kumar Dogra, Sanjay Dvivedi   +5 more
doaj   +1 more source

Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification. [PDF]

PLoS ONE, 2017
OBJECTIVES:Vascular calcification is a frequent complication in chronic haemodialysis patients and is associated with adverse outcomes. Serum calcium and phosphate levels and imbalances in calcification regulators are thought to contribute to the process.
Daniel Azpiazu, Emilio González-Parra, Alberto Ortiz, Jesús Egido, Ricardo Villa-Bellosta   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Response surface analysis of rat bone composition changes by dietary calcium and silicon [PDF]

, 2003
Plan BSilicon (Si) apparently is involved in bone calcification; however, its affect appears to be related to dietary calcium. The objective of this experiment was to determine the effects of varying concentrations of dietary silicon on bone ...
McCrady, Shelly
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source