Results 81 to 90 of about 3,792,621 (302)

Calcium – a possible element behind hypertension [PDF]

Romanian Journal of Medical Practice
Background. Hypertension is the one of the important reasons of mortality and morbidity worldwide which affects around 6% to 32% of the general population.
Jagadeswar KAKUMANI, Fahad Mohammedamin DADU, Arun KUMAR B, Ramkumar MURALI, Magesh KUMAR S   +4 more
doaj   +1 more source

Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease.

Kidney International, 2007
Abnormalities of mineral metabolism occur early in chronic kidney disease. Quantification of the prevalence of these abnormalities has not been described using current assays nor in large unselected populations.
A. Levin, G. Bakris, M. Molitch, M. Smulders, J. Tian, L. Williams, D. Andress   +6 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Effect of Feeding a Calcium Chloride Supplement on Sow Stillbirth Rate

Animals
The present study was undertaken to determine the effect of daily calcium chloride (CaCl2) supplementation from day of entry into the farrowing house until day of farrowing (6.4 ± 0.3 d) on stillbirth rates.
Sahara Craig, Si-En Ruth Khaw, Kiro R. Petrovski, Roy N. Kirkwood   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

PLoS Genetics, 2013
Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown.
C. O'Seaghdha, Hongsheng Wu, Qiong Yang, K. Kapur, I. Guessous, A. M. Zuber, A. Köttgen, Candice Stoudmann, A. Teumer, Z. Kutalik, M. Mangino, A. Dehghan, Weihua Zhang, G. Eiriksdottir, Guo Li, Toshiko Tanaka, L. Portas, Lorna M. Lopez, C. Hayward, K. Lohman, K. Matsuda, S. Padmanabhan, D. Firsov, R. Sorice, Sheila Ulivi, A. Brockhaus, M. Kleber, A. Mahajan, F. Ernst, V. Gudnason, L. Launer, A. Macé, Eric Boerwinckle, D. Arking, C. Tanikawa, Yusuke Nakamura, Morris J. Brown, J. Gaspoz, J. Theler, D. Siscovick, B. Psaty, S. Bergmann, P. Vollenweider, V. Vitart, A. Wright, T. Zemunik, M. Boban, I. Kolčić, P. Navarro, E. Brown, K. Estrada, Jingzhong Ding, T. Harris, S. Bandinelli, D. Hernandez, A. Singleton, G. Girotto, D. Ruggiero, A. d’Adamo, A. Robino, T. Meitinger, C. Meisinger, G. Davies, J. Starr, J. Chambers, B. Boehm, B. Winkelmann, Jie Huang, Federico Murgia, S. Wild, H. Campbell, A. Morris, O. Franco, A. Hofman, A. Uitterlinden, F. Rivadeneira, U. Völker, A. Hannemann, R. Biffar, W. Hoffmann, So-Youn Shin, P. Lescuyer, Hughes Henry, C. Schurmann, P. Munroe, P. Gasparini, N. Pirastu, M. Ciullo, C. Gieger, W. März, L. Lind, T. Spector, A. Smith, I. Rudan, James F. Wilson, O. Polašek, I. Deary, M. Pirastu, L. Ferrucci, Yongmei Liu, B. Kestenbaum, J. Kooner, J. Witteman, M. Nauck, W. Kao, H. Wallaschofski, O. Bonny, C. Fox, M. Bochud   +108 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source