Results 31 to 40 of about 1,024,802 (210)

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Biochemical testing and pathology reveal rare cause of pediatric acute liver failure: Hyperornithinemia‐hyperammonemia‐homocitrullinuria syndrome

JPGN Reports, EarlyView.
Abstract Hyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome is a rare metabolic condition that can cause lethargy, ataxia, tachypnea, nausea, vomiting, seizures, coma, and acute liver failure. We present a 26‐month‐old female with acute liver failure who was diagnosed with HHH 1 week after admission. Histology revealed an acute hepatitic
Tierra L. Mosher, Kathryn S. Czepiel, Matthew B. Neu, Andrea Carolina Cortes Fernandez, L. Walden Browne, Annie D. Niehaus, Roberto Gugig   +6 more
wiley   +1 more source

Comparison of copper concentration between non-alcoholic fatty liver disease patients and normal individuals: A meta-analysis

Frontiers in Public Health, 2023
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Copper metabolism plays an important role in the pathogenesis of NAFLD.
Yanfang Chen, Chutian Wu, Guanhong Li, Wen Wang, Shaohui Tang   +4 more
doaj   +1 more source

Suspected fibrosing cholestatic hepatitis in an immunocompetent child with hepatitis C: Case report

JPGN Reports, EarlyView.
Abstract A 12‐year‐old boy presented to our center with elevated aminotransferases, jaundice, right upper quadrant tenderness, and hepatomegaly. Evaluation revealed a highly elevated blood hepatitis C virus (HCV) ribonucleic acid (RNA) level, and liver biopsy showed canalicular and intrahepatic cholestasis, feathery degeneration of hepatocytes, and ...
Sara Bohon, Regino Gonzalez‐Peralta, Robert J. Fontana, Richard Cordle, Robin LeGallo, Frank DiPaola   +5 more
wiley   +1 more source

Serum ceruloplasmin and striatal dopamine transporter density in Parkinson disease: Comparison with 123I-FP-CIT spect

, 2019
Purpose In patients with Parkinson disease (PD), decreased serum ceruloplasmin levels have been observed. This study investigated a correlation between serum ceruloplasmin - along with its related serum markers -and striatal presynaptic dopaminergic ...
윤지영
core   +1 more source

More than just anemia: Uncovering celiac disease beneath the surface: A case report

JPGN Reports, EarlyView.
Abstract Celiac disease (CD) is an immune‐mediated disorder triggered by gluten in genetically susceptible individuals. Although iron deficiency anemia is a common presentation, other micronutrient deficiencies may occur. We describe a 3.5‐year‐old female whose initial presentation of CD was severe, asymptomatic normocytic anemia secondary to copper ...
Evan Greenhall, Bri Best, David F. Carpenteri, Paula Prieto‐Tizzard   +3 more
wiley   +1 more source

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Psychiatry and Clinical Psychopharmacology, 2019
OBJECTIVE: In this study, we aimed to study copper metabolism in schizophrenia, bipolar disorder, major depression compared with healthy control. METHODS: This is a single-centered cross-sectional study.
Serhat Tunç, Murat İlhan Atagün, Hamit Serdar Başbuğ, Özcan Erel   +3 more
doaj   +1 more source

Correlação entre a atividade sérica da ceruloplasmina e os teores sérico e hepático de cobre em novilhas Nelore Ceruloplasmin serum activity correlation with copper serum and liver concentrations in Nelore heifers

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2005
Avaliou-se a atividade oxidativa sérica da ceruloplasmina como indicadora dos teores sérico e hepático de cobre e compararam-se dois métodos de determinação da ceruloplasmina, pelo parafenileno e pela ortodianisidina. Foram colhidas 56 amostras de soro e
A.S. Borges, R.M. Amorim, M.R.G. Kuchembuck, R.S. Araújo, S.B. Silva, H.F. Silva, F.J. Benesi, R. Mirandola, M. Morgano   +8 more
doaj   +1 more source

Association of serum trace elements with non-invasive fibrosis scores in metabolic dysfunction-associated steatotic liver disease

Scientific Reports
Liver biopsy is not a routine screening tool for detecting fibrosis progression in metabolic dysfunction-associated steatotic liver disease (MASLD). Noninvasive methods based on serum biomarkers are used instead.
Erfan Banisefid, Sahand Karkon Zonouzi, Sina Hamzehzadeh, Zeinab Nikniaz, Seyedehyasmin Moghaddamziabari, Leila Alizadeh   +5 more
doaj   +1 more source