Results 101 to 110 of about 2,079,920 (381)

FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

Advanced Science, EarlyView.
F‐box only protein 2 (FBXO2) combats intervertebral disc degeneration (IVDD) by coordinating dual protection. It activates PTEN‐induced putative kinase 1 (PINK1)‐Parkin mitophagy restoring mitochondrial function and targets lipocalin‐2 (LCN2) for degradation, suppressing ferroptosis.
Tongde Wu, Yanjin Wang, Beiduo Shen, Kai Guo, Ziqi Zhu, Yongzhou Liang, Jianhua Zeng, Desheng Wu   +7 more
wiley   +1 more source

Low Dose Daily Iron Supplementation Improves Iron Status and Appetite but not Anemia, Whereas Quarterly Anthelminthic Treatment Improves Growth, Appetite and Anemia in Zanzibari Preschool Children. [PDF]

, 2004
Iron deficiency and helminth infections are two common conditions of children in developing countries. The consequences of helminth infection in young children are not well described, and the efficacy of low dose iron supplementation is not well ...
Adam, Albonico, Albonico, Antonio Montresor, Brown, Caulfield, Crompton, Davis, de Andraca, Dickson, Diggle, Donnen, Freij, Greenberg, Gupta, Gupta, Hababu M. Chway, Idjradinata, James M. Tielsch, Jape Khatib Jape, Jelkmann, Kloetzel, Lackritz, Langhans, Levin, Lorenzo Savioli, Lozoff, Marco Albonico, Menendez, Montresor, National Research Council, Nelson, Pelletier, Pinero, Plata-Salaman, Rebecca J. Stoltzfus, Reeds, Rosenberg, Rousham, Savioli, Schultz, Smith, Solomons, Stoltzfus, Stoltzfus, Stoltzfus, Stoltzfus, Thein-Hlaing, Trape, Verhoef, Warren, Willett, World Health Organization, World Health Organization Expert Committee   +53 more
core   +1 more source

Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD

International Journal of Molecular Sciences, 2016
Nonalcoholic fatty liver disease (NAFLD), tightly linked to the metabolic syndrome (MS), has emerged as a leading cause of chronic liver disease worldwide.
R. Lombardi, G. Pisano, S. Fargion
semanticscholar   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

Advanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia, Yan Liu, Yangkun Xing, Zhewei Shi, Xiaocheng Pang   +4 more
wiley   +1 more source

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]

, 2020
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P., Lagana, B., Pioli, C., Rosado, M. M., Sesti, G.   +4 more
core   +2 more sources

SNORA58 Facilitates Radioresistance via Suppressing JNK1‐Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
In ESCC patients, SNORA58 exhibits heterogeneous expression patterns. Its aberrant overexpression stabilizes CTCF by inhibiting ubiquitin‐mediated degradation, leading to the attenuation of JNK1‐mediated ferroptosis induced by radiotherapy through disruption of intracellular iron homeostasis, and ultimately contributes to radioresistance ...
Yinli Zheng, Fangyi Liu, Yuhua Huang, Yanfen Feng, Xia Yang, Jinjun Wu, Xin Yang, Xuanhao Lin, Lives Jiang, Tingting Zeng, Yan Li, Xinyuan Guan, Yuanyuan Wang, Chunyan Chen, Jingping Yun   +14 more
wiley   +1 more source

The effect of amino acid deprivation on the transfer of iron through Caco-2 cell monolayers [PDF]

, 2017
Funding Source Rural and Environmental Scientific and Analytical Services, the Scottish Government Acknowledgments We thank Dr Helen Hayes for her technical support during this project.
Cottin, Sarah, McArdle, Harry J., Roussel, Guenievre, Stevens, Valerie   +3 more
core   +2 more sources

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Evaluation of Serum Ferritin Levels in Patients of Hypothyroidism [PDF]

Indian Journal of Medical Biochemistry
Background: The thyroid gland is a bilobed endocrine gland that secretes two vital hormones: thyroxine (T4) and triiodothyronine (T3). The production and release of these hormones are regulated by the thyroid-stimulating hormone (TSH) from the pituitary ...
Vartika Saini, Sunny Chopra, Jaspinder Kaur, Maninder Kaur   +3 more
doaj   +1 more source

Development and validation of the prognostic value of ferritin in adult patients with Hemophagocytic Lymphohistiocytosis

Orphanet Journal of Rare Diseases, 2020
Background Hemophagocytic Lymphohistiocytosis (HLH) is a rare clinical syndrome with high mortality rate. The diagnosis of HLH draws on a constellation of clinical and laboratory abnormalities including extremely high serum ferritin levels.
Jun Zhou, Jing Zhou, Dan-Ting Shen, Hemant Goyal, Zhi-Qi Wu, Hua-Guo Xu   +5 more
doaj   +1 more source