Results 231 to 240 of about 2,079,920 (381)

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

open access: yesVIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan   +6 more
wiley   +1 more source

Impaired Cytokine Secretion Contributes to Age‐Dependent Immune Dysfunction in SARS Coronavirus Response and Is Restored by Young CD11b‐Positive Cell Transfer

open access: yesAging Cell, EarlyView.
Aged CD11b+ cells exhibit impaired IRF7 activation and reduced SNARE protein expression, leading to delayed interferon responses and diminished cytokine secretion. These dual deficits may contribute to the heightened susceptibility of older individuals to severe outcomes following SARS‐CoV infection.
Yu‐Xuan Wu   +10 more
wiley   +1 more source

Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

open access: yesAging Cell, EarlyView.
In the CA1, microglia are activated to be responsible for synaptic pruning. However, LPS induces a senescent phenotype in microglia, characterized by the elevated levels of p16, as well as the production of SASPs. These senescent microglia mediate the removal of excitatory synapses selectively, resulting in dendritic spine loss and LTP impairment ...
Kai Liu   +8 more
wiley   +1 more source

Association between weight-adjusted-waist index and serum ferritin in patients with type 2 diabetes. [PDF]

open access: yesAsia Pac J Clin Nutr
Wang Y   +7 more
europepmc   +1 more source

The role of iron in normal and impaired testicular function

open access: yesAndrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer   +2 more
wiley   +1 more source

Correlation of Serum Ferritin with Lipid Profile in β-Thalassemia Patients

open access: yesJK Science
Background: The present study was aimed to study alterations in lipid levels and its corelation with ferritin in Thalassemia patients. Methods: 50 patients of diagnosed Thalassemia in age group of 9 to 12 years were included in the study and results ...
Salunkhe Vaishnavi Sandip   +2 more
doaj  

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