Results 281 to 290 of about 2,346,531 (347)

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

A Hybrid Nanosystem for Prostate Cancer Therapy: Codelivery of Enzalutamide and Curcumin via Selenium‐Embedded Mesoporous Silica and Chitosan Nanoparticles

ChemistryOpen, Volume 15, Issue 3, March 2026.
Herein, solvent extraction was selected for cetyltrimethylammonium bromide removal and the development of optimized Se‐embedded mesoporous silica nanoparticles, which were loaded with enzalutamide. Additionally, to improve the anticancer activity of Se@MSNPs‐Enz and curcumin bioavailability, curcumin‐loaded chitosan nanoparticles were prepared. This pH‐
Zahra Tavakoli, Khosro Khajeh, Bijan Ranjbar   +2 more
wiley   +1 more source

Folinic Acid Supplementation in Folate Receptor Alpha Autoantibodies‐Positive Pregnancy: A Pilot Randomized Study on Neurodevelopmental Outcomes

Reproductive, Female and Child Health, Volume 5, Issue 1, March 2026.
ABSTRACT Background Folate receptor alpha autoantibodies (FRAAs) during pregnancy may impair placental folate transport, contributing to cerebral folate deficiency and increasing the risk of neurodevelopmental disorders such as autism spectrum disorder (ASD).
Claudio Giorlandino, Alvaro Mesoraca, Katia Margiotti, Marco Fabiani, Marina Cupellaro, Francesca Giorlandino, Maria Luisa Mastrandrea, Raffaella Raffio, Francesco Pignataro, Lucia Mangiafico, Laura D'Emidio, Claudio Coco, Vincenzo Milite   +12 more
wiley   +1 more source

Personalized Nutrition Recommendations Using a Bayesian Mixture Model of Concentration Constraints and Intake Preferences

Statistics in Medicine, Volume 45, Issue 6-7, March 2026.
ABSTRACT Maintaining proper nutrition is crucial for preserving health and preventing disease. However, what constitutes proper nutrition may vary among individuals; evidence indicates that the effects of diet and even single nutrients can differ considerably because of personal characteristics.
Jari Turkia, Ursula Schwab, Ville Hautamäki   +2 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, Volume 22, Issue 16, 17 March 2026.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow‐Up, and Complex Disease Courses

United European Gastroenterology Journal, Volume 14, Issue 2, March 2026.
ABSTRACT Introduction Since the publication of the first European Society for the Study of Coeliac Disease (ESsCD) guidelines in 2019, substantial advances have been made in understanding the management and complex disease courses of coeliac disease (CeD) in adults.
Abdulbaqi Al‐Toma, Federica Branchi, Fabiana Zingone, Annalisa Schiepatti, Georgia Malamut, Cristina Canova, Isabella Rosato, Honoria Ocagli, Nick Trott, Luca Elli, Alina Popp, Carmen Gianfrani, Renata Auricchio, Andra Neefjes‐Borst, David S. Sanders, Christophe Cellier, Chris J. Mulder, Gerd Bouma, Knut E. A. Lundin, Ludvig M. Sollid, Michael Schumann   +20 more
wiley   +1 more source

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Relationship of several serum folate forms with the risk of mortality: A prospective cohort study.

Clinical Nutrition, 2021
OBJECTIVE We aim to examine the relation of several folate forms (5-methyltetrahydrofolate [5-mTHF], unmetabolized folic acid [UMFA], non-methyl folate, and MeFox [pyrazino-s-triazine derivative of 4α-hydroxy-5-methyltetrahydrofolate]) with the risk of ...
Mengyi Liu, Zhuxian Zhang, Chun Zhou, Qinqin Li, P. He, Yuanyuan Zhang, Huan Li, Chengzhang Liu, M. Liang, Xiaobin Wang, Xiping Xu, F. Hou, X. Qin   +12 more
semanticscholar   +1 more source

ORAL CONTRACEPTIVES AND SERUM-FOLATE LEVEL

The Lancet, 1968
Serum folate levels were determined microbiologically with Lactobacillus casei in 24 normal nonpregnant women of childbearing age and in 62 women using oral contraceptives (Ortho-Novum Ovulen C-Quens Norinyl Enovid-E) for 2 months to 5 years.
A M, Shojania, G, Hornady, P H, Barnes
openaire   +2 more sources