Results 161 to 170 of about 1,646,017 (264)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Serum Proteins Predict Treatment-Related Cardiomyopathy Among Survivors of Childhood Cancer. [PDF]

JACC CardioOncol
Poudel S, Shrestha H, Pan Y, Li Q, Li K, Im C, Dixon SB, Ehrhardt MJ, Mulrooney DA, Zhou S, Tan H, High AA, Burridge PW, Bhatia S, Jefferies JL, Ness KK, Hudson MM, Robison LL, Armstrong GT, Peng J, Ky B, Yasui Y, Sapkota Y.   +22 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Screening and verification of differentially expressed serum proteins in children with severe adenovirus pneumonia. [PDF]

Front Public Health
Gao ZX, Xu H, Yang Q, Xie L, Chen LN, Liu HM.   +5 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A Grignard-mediated route to access 4-substituted-3-<i>E</i>-styryl-2<i>H</i>-chromenes: alternate extrinsic FRET probes to explore the IIA and IIIA subdomains of serum proteins. [PDF]

RSC Adv
Rakshit S, Bhar S, Roy R.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis. [PDF]

J Dent Res
Wänman M, Betnér S, Esberg A, Holm CK, Isehed C, Holmlund A, Palmqvist P, Lövgren A, Lindquist S, Hänström L, Lerner UH, Kindstedt E, Lundberg P.   +12 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Proteomic Analysis of Human Serum Proteins Adsorbed onto Collagen Barrier Membranes. [PDF]

J Funct Biomater
Shanbhag S, Al-Sharabi N, Fritz-Wallace K, Kristoffersen EK, Bunæs DF, Romandini M, Mustafa K, Sanz M, Gruber R.   +8 more
europepmc   +1 more source