Results 71 to 80 of about 1,640,389 (263)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A taxonomical study on electrophoretic pattern of blood serum protein of some fish of karakaya dam lake [PDF]

Eurasian Journal of Veterinary Sciences
In this study, an electrophoretic comparison of serum blood proteins of two species of fish, Capoeta trutta and Capoeia capoeta umbla, were carried out. Study was carried between june and october in 1997. Using the Random Sampling Method, 92 C.
Muhittin Yılmaz, Yusuf Türköz, A. Ümit Erdemli, Ercan Kalkan, Yılmaz Çİğremiş   +4 more
doaj  

Changes in blood serum protein profile in low-yielding ewes during the periparturient period

Open Veterinary Journal
Background: In high-yielding dairy ewes, metabolic and reproductive processes occurring around the time of parturition and during lactation initiation are accompanied by several changes in blood biochemical parameters, including those related to protein
Veronika Glembova, Csilla Tóthova, Veronika Oršuľakova, Oskar Nagy   +3 more
doaj   +1 more source

Proteomic evaluation of sheep serum proteins

BMC Veterinary Research, 2012
Background The applications of proteomic strategies to ovine medicine remain limited. The definition of serum proteome may be a good tool to identify useful protein biomarkers for recognising sub-clinical conditions and overt disease in sheep.
Chiaradia Elisabetta, Avellini Luca, Tartaglia Micaela, Gaiti Alberto, Just Ingo, Scoppetta Fausto, Czentnar Zoltan, Pich Andreas   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Association Between Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population

Biomedicines
Background: Population differences in gut microbiota composition and related metabolites may influence their potential causal relationship with chronic kidney disease (CKD); however, this relationship remains poorly understood in the Chinese population ...
Wenjian Lin, Zixin Liang, Junxuan Fang, Yu Liu, Lei Lei, Jiawen Lin, Bin Xia, Zhihua Zheng, Jingqiu Yuan, Chun Tang   +9 more
doaj   +1 more source

Conversion of Serum Proteins into Tissue Proteins.

Experimental Biology and Medicine, 1959
Summary1. Incorporation of S35 and C14 from injected doubly labeled rat serum albumin or globulin into the tissue proteins of rats was investigated. The ratio S35/C14 in tissue proteins varies very little during 9 days after injection of the doubly labeled serum proteins. 2.
S, FLEISCHER, A, LIETZE, H, WALTER, F, HAUROWITZ   +3 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

"STUDY OF Gc, Cp, C3 , IgG , IgA AND IgM LEVELS IN PATIENTS WITH ESOPHAGEAL CARCINOMA IN IRAN " [PDF]

Iranian Journal of Public Health, 1997
Quantitative serum level measurements of Gc , Cp , C3 , IgG , IgA and 1gM were carried out on 102 patients with esophageal carcinoma following laryngectomy, in comparison with 66 healthy individuals as controls, in Gonbad area, north east of Iran.
D.D. Farhud, H. Sadighi, C. Azimi, Z. Mazhari, M.A. Eftekhari, M. Mahmoudi, N. Nikzat   +6 more
doaj   +1 more source

SERUM PROTEIN CHANGES IN RABBITS AFTER CHRONIC ADMINISTRATION OF LEAD AND CADMIUM [PDF]

Journal of Central European Agriculture, 2008
The infl uence of lead (5mg/kg b.w) and cadmium (2mg/kg b.w) after chronic treatment of the rabbits on serum protein is investigated. Signifi cantly raised content of the cholesterol, ASAT and ALAT; hypo-albuminemia and hyperbetaglobulinemia of the ...
Hristo HRISTEV, Dimo PENKOV, Abdul Hallak, Maria Kirova, Bayko Baykov, Atanas Bliznakov   +5 more
doaj