Results 51 to 60 of about 7,323,907 (261)

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Dermatomyositis associated with omalizumab therapy for severe asthma: a case report

Allergy, Asthma & Clinical Immunology, 2019
Background Omalizumab is a humanized monoclonal antibody widely used for treatment of persistent allergic asthma and antihistamine-refractory chronic urticaria. Immediate adverse events to omalizumab are well characterized.
Samira Jeimy, Pari Basharat, Fiona Lovegrove   +2 more
doaj   +1 more source

Serum Sickness in Patients Receiving Equine Rabies Immunoglobulin [PDF]

, 2018
Background: Equine Rabies Immunoglobulin (ERIG) is being used for treatment of category-III animal bite cases. ERIG is economical as compared to Human Rabies Immunoglobulin (HRIG) and hence more affordable to patients in developing countries, like India.
Pattanaik, Nupur, Maharana, Sabita, Behera, Tapas Ranjan   +2 more
core  

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Systemic illness with eosinophilia and urticaria-like rash caused by prolonged bedbug exposure

International Journal of Infectious Diseases
Bedbugs are blood-feeding nocturnal ectoparasites, which are well-adapted to human habitats. In recent decades, bedbug infestation has been an emerging health problem worldwide, affecting all socio-economic population strata.
Ian B. Weitzel, Valeria Palma, Macarena Silva, Alex Castro, Thomas Weitzel   +4 more
doaj   +1 more source

Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis [PDF]

, 2008
Sleeping sickness is caused by a species of trypanosome blood parasite that is transmitted by tsetse flies. To understand better how infection with this parasite leads to disease, we provide here the most detailed description yet of the course of ...
Thuita, J.K., John K. Thuita, Mwangangi, D., C. M. R. Turner, Matovu, E., Masiga, D., Enock Matovu, Kagira John M., John K Thuita, Kagira, J.M., John M. Kagira, David Mwangangi, Turner, C.M.R., Thuita John K., Masiga Daniel, Mwangangi David, Matovu Enock, C M R Turner, Daniel Masiga, Turner C. M. R., John M Kagira   +20 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

A powerful intervention: general practitioners' use of sickness certification in depression [PDF]

, 2012
<b>Background</b> Depression is frequently cited as the reason for sickness absence, and it is estimated that sickness certificates are issued in one third of consultations for depression. Previous research has considered GP views of sickness
Whittaker, Will, Sara Macdonald, Whittaker, William, Sutton , Matt, Maxwell Margaret, Maxwell, M., Wilson, P, Whittaker, W., Morrison , Jill, Maxwell, M, Wilson, P., Michael Smith, Wilson, Philip, Macdonald, Sara, MacDonald, S, Whittaker, W, Macdonald Sara, Smith, M, Sutton Matt, Margaret Maxwell, Philip Wilson, Will Whittaker, Smith, M., Sutton, M., Wilson Philip, Macdonald, Sara R, Smith, Michael, Macdonald, S., Morrison, J, Whittaker, Will; id_orcid, Matt Sutton, Sutton, M, Whittaker Will, Morrison Jill, Morrison, J., Maxwell, Margaret, Smith Michael, Jill Morrison, Sutton, Matt, Morrison, Jill   +39 more
core   +2 more sources

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source