Results 221 to 230 of about 3,665,696 (260)

Pyroptosis in Preeclampsia: Placenta‐to‐Maternal Organ Communication, Molecular Mechanisms, and Therapeutic Targets

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou, Liming Yuan, Ya Li, Rong Zhou, Linbo Gao, Xiaohong Wei   +5 more
wiley   +1 more source

Predicting cardiovascular disease in peritoneal dialysis patients using glycated proteomics and machine learning: A prospective multicentre study

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Graphical Headlights 1. Glycated proteomics identified candidate cardiovascular biomarkers in peritoneal dialysis patients. 2. A machine learning model integrated two glycated peptides with six clinical indicators. 3. The model achieved ROC‐AUCs of 0.781 in the internal testing set and 0.822 in multicentre external validation.
Ji Ji, Zhaoying Nie, Na Jiang, Ting Xie, Lei Zhang, Xiaoyan Liu, Min Lu, Bo Xiang, Weiwei Wu, Xiaotian Jiang, Lin Zhang, Jun Ji, Jianzhou Zou, Xiaoqiang Ding, Haojie Lu, Xiaofang Yu   +15 more
wiley   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

Body Composition Phenotypes and Their Metabolic Associations in Treatment‐Naïve Patients With Newly Diagnosed Type 2 Diabetes: A DXA‐Based Cluster Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Using dual‐energy X‐ray absorptiometry clustering of 185 treatment‐naïve type 2 diabetes patients, we identified four body‐composition phenotypes. Central‐obesity and high‐fat–high‐muscle clusters carried the highest fatty liver disease and hyperuricemia risk, whereas the low‐muscle cluster carried the highest osteoporosis risk.
Xintong Zhang, Rui Zhang, Tao Jiang
wiley   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

Dietary Interventions May Mitigate Health Risks of Per‐ and Polyfluoroalkyl Substances (PFAS) Exposure Through Modulation of the Gut Microbiota: A Review

Food Frontiers, Volume 7, Issue 6, November 2026.
Dietary interventions, including probiotics, prebiotics, and synbiotics, may modulate gut microbiota to regulate PFAS accumulation and elimination. Specific microbial taxa facilitate PFAS removal through adsorption and bioaccumulation, potentially reducing internal PFAS burden and mitigating PFAS‐related health risks.
Jiahui Xia, Xueqing Li, Mingluan Xing, Huixia Niu, Lizhi Wu, Xin Gong, Longxiao Liu, Zhijian Chen, Xiaoming Lou, Pengcheng Tu   +9 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

What Is Your Diagnosis? Lymph Node Aspirate From a Dog

Veterinary Clinical Pathology, EarlyView.
William Benedict, Emily Rout, Lori Cesario, A Russell Moore   +3 more
wiley   +1 more source

Short‐ and Long‐Term Control of Hypertension After Bariatric Surgery: A 10‐Year Prospective Study

MedComm, Volume 7, Issue 11, November 2026.
ABSTRACT Current guidelines support bariatric surgery (BS) as an effective treatment mainly for patients with severe obesity and poorly controlled hypertension. However, evidence in non‐severely obese Asian populations remains limited. This multicenter prospective cohort study included 248 Chinese patients with obesity and hypertension who underwent BS
Xiaoxiao Zhong, Yaoquan Cao, Xulong Sun, Pengzhou Li, Weizheng Li, Hong Yuan, Shaihong Zhu, Liangping Wu, Hua Meng, Yao Lu, Liyong Zhu   +10 more
wiley   +1 more source

Pharmacological and Therapeutic Potential of Garlic (Allium sativum): Integrating Phytochemistry, Molecular Mechanisms, and Clinical and Preclinical Evidence

ChemistryOpen, Volume 15, Issue 11, November 2026.
Garlic bioactive compounds, including organosulfur compounds (allicin, DADS, DATS, and SAC), phenolic compounds, and quercetin, regulate the Nrf2/HO‐1, NF‐κB, PI3K/Akt, and AMPK/eNOS signaling pathways. These actions enhance antioxidant defenses, suppress inflammation, improve metabolic and cardiovascular function, and contribute to reduced blood ...
Gudisa Bereda
wiley   +1 more source