Results 231 to 240 of about 3,665,696 (260)

Association between fasting serum uric acid levels and Alzheimer's disease in nursing home residents: a cross-sectional study. [PDF]

Front Nutr
Lin X, Zhao W, Zhou J, Qiu J.
europepmc   +1 more source

Bone Anabolic Treatment in Patients With Chronic Kidney Disease: A Systematic Review

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Background Chronic kidney disease (CKD) associated osteoporosis leads to an increased risk of bone fracture in patients with CKD. Evidence on the efficacy and safety of anti‐osteoporotic medications is limited for this group. This systematic review aimed to examine the efficacy and safety of anabolic parathyroid hormone (PTH) treatment in ...
Huriye Seyma Kafa, Sabina Chaudhary Hauge, Ditte Hansen   +2 more
wiley   +1 more source

Association of Serum Uric Acid With Cardiovascular-Kidney-Metabolic Risk in a Rural Indian Population. [PDF]

JACC Asia
Mohanraj S, Vasudevan SA, Raghupathy AK, Seenivasan SN, Durairaj K, Gajendran B, Ayothi P, Baskar MK, Manivel G, Sambandam M, Velmurugan G, Shanmugam J, Cherian M, Alexander T, Swaminathan K, Ramakrishnan A.   +15 more
europepmc   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

The causal associations of serum uric acid levels and gout with the risk of acute pancreatitis: A bidirectional Mendelian randomization study. [PDF]

Medicine (Baltimore)
Lin Y, Zheng Q, Peng L, Chen M, Zhang C, Chen S.   +5 more
europepmc   +1 more source

The Association Between Serum Uric Acid to Creatinine Ratio and the Severity of Acute Pancreatitis. [PDF]

Pancreas
Xu Y, Wang Y, Yu Q, Huang X, Li J, Zhang X, Chen X, Chen Y.   +7 more
europepmc   +1 more source

Serum uric acid in pediatric metabolic assessment: the scientific rationale for routine screening and the urgent need for age- and sex-specific diagnostic thresholds. [PDF]

Front Nephrol
Salomon I, Ndamukunda Y, Solange M, Zeleke EE.   +3 more
europepmc   +1 more source

Serum Uric Acid Levels and the Risk of Breast Cancer and Benign Breast Tumors: A Systematic Review and Meta-Analysis. [PDF]

Health Sci Rep
Mo H, Liao W, Chen X, Li M, Wang M, Li Y.   +5 more
europepmc   +1 more source

Empagliflozin improves serum uric acid and early cardiometabolic outcomes in asymptomatic hyperuricemia among patients with type 2 diabetes: A 6-month observational study. [PDF]

Medicine (Baltimore)
Nguyen MQD, Tran KDD, Tran SK.
europepmc   +1 more source

Association of serum uric acid with circulating inflammatory proteins and treatment response to ixekizumab in patients with psoriasis: A multicenter prospective cohort study in China. [PDF]

Chin Med J (Engl)
Jiang Y, Guo Z, Yao L, Huang D, Ma R, Zhong X, Wang Y, Lu J, Li Y, Shi Y.   +9 more
europepmc   +1 more source