Results 51 to 60 of about 3,665,696 (260)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer. [PDF]

Cancer Sci
Using both conventional observational and Mendelian randomization (MR) analyses in the same Japanese community‐dwelling population, the evidence consistently supported an inverse association between the serum uric acid level and lung cancer risk. ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a ...
Matsunaga T, Wakai K, Tamura T, Nagayoshi M, Okada R, Kageyama I, Hara M, Furukawa T, Ikezaki H, Matsumoto Y, Nishiyama T, Nakagawa-Senda H, Koriyama C, Tanoue S, Takashima N, Ozaki E, Miura K, Kadota A, Watanabe T, Ishizu M, Kuriki K, Nakatochi M, Momozawa Y, Imoto I, Oze I, Matsuo K, J‐MICC Study Group.   +26 more
europepmc   +2 more sources

Relationship between dietary patterns and serum uric acid concentrations among ethnic Chinese adults in Taiwan

, 2014
The evidence for a relationship between dietary patterns and uric acid concentrations is scanty. Here, we used a validated food frequency questionnaire for an ethnic Chinese population in Taiwan to investigate the relationship between dietary patterns ...
Tsai, Yi-Tsen;Liu, Jen-Pei;Tu, Yu-Kang;Lee, Meei-Shyuan;Chen, Pey-Rong;Hsu, Hsiu-Ching;Chen, Ming-Fong;Chien, Kuo-Liong, 陳珮蓉 ;陳明豐 ;簡國龍 ;許秀卿   +1 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Association between Serum Uric Acid Levels and Diabetes Mellitus

International Journal of Endocrinology, 2011
Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease in previous studies. However, few studies have examined the association between serum uric acid and diabetes mellitus and their findings
Pavani Bandaru, Anoop Shankar
doaj   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

The distribution chart of serum uric acid.

, 2014
The distribution chart of serum uric acid.
Ye-Ping Ren (296328), Tong-Ying Zhu (296327), Na Tian (296333), Hui-Ping Zhao (296330), Xiao-Hui Zhang (180568), Meng-Hua Chen (296331), Jie Dong (12143), Qing-Feng Han (296326), Yue Wang (65477), Hai-Yan Wang (168261), Chuan-Ming Hao (296332), Rui Zhang (13940), Jiang-Hua Chen (296329), Rong Xu (296325), Mei Wang (130842)   +14 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013–2020

BMC Women's Health, 2023
Background There is limited concrete evidence connecting serum uric acid levels to female infertility. Therefore, this study aimed to find out if serum uric acid levels are independently related to female infertility. Methods From the National Health and
Jiemei Liang, Xiting Chen, Jinfa Huang, Weizhe Nie, Qian Yang, Qitao Huang, Kaixian Deng   +6 more
doaj   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source