Results 41 to 50 of about 3,072 (244)

N parallel queueing systems with server breakdown and repair [PDF]

open access: yesEuropean Journal of Operational Research, 1995
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Analysis of an M[X]/(G1,G2)/1 retrial queueing system with balking, optional re-service under modified vacation policy and service interruption

open access: yesAin Shams Engineering Journal, 2014
This paper deals with the steady state analysis of batch arrival retrial queueing system with two types of service under modified vacation policy, where each type consists of an optional re-service.
P. Rajadurai   +2 more
doaj   +1 more source

An Optimal Rejuvenation Strategy for Increasing Service Reliability of a VOIP System with Multiple Components [PDF]

open access: yesInternational Journal of Mathematical, Engineering and Management Sciences, 2017
In this day and age Voice over Internet Protocol (VoIP) has turned out to be a revolutionary technology in the field of telecommunication. Because of the escalating number of users of VoIP, it is essential to intend for a reliable VoIP system providing ...
Vandana Gupta, Rahul Kumar
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

HGDiscovery: An online tool providing functional and phenotypic information on novel variants of homogentisate 1,2- dioxigenase

open access: yesCurrent Research in Structural Biology, 2022
Alkaptonuria (AKU), a rare genetic disorder, is characterized by the accumulation of homogentisic acid (HGA) in the body. Affected individuals lack functional levels of an enzyme required to breakdown HGA.
Malancha Karmakar   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The well-posedness of an M/G/1 queue with second optional service and server breakdown

open access: yes, 2009
In this paper, the solution of an M/G/1 queue with second optional service and server breakdown is investigated. By using the method of functional analysis, especially, the linear operator theory and the C0 semigroup theory on Banach space, we prove the ...
Wang, Wen-Long, Xu, Gen-Qi
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

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