Results 71 to 80 of about 2,185,055 (279)
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source
Retrial G-queue with precipitous breakdown and non-tenacious customers [PDF]
Yugoslav Journal of Operations ResearchWe perform an analysis on an M/G/1 system that has bulk arrival Poisson process as well as instantaneous service, Precipitous breakdown and random repair, Gqueue, and operation under an MBV (Modified Bernoulli vacation) policy.
Bharathi Jagannathan +1 more
doaj +1 more source
Single Server Queue with Server Breakdown Including Priority and Varying Rates
Journal of King Abdulaziz University-Engineering Sciences, 1999 A single server queueing system with service interruption due to failure of the major/minor service unit has been studied. The job's inter-arrival time as well as the failure time and the repair time of the major/minor service unit are assumed to be exponentially distributed. The arrival of the jobs to the service facility consisting of major and minor
openaire +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Modelling the response rate of Apache web server using extreme value theory
Scientific AfricanDelay in response is associated with servers used in processing data particularly when there is large number of users. Consequently, the performance of web servers plays a crucial role in the digital ecosystem, necessitating analysing their tail ...
Hamed Akintayo Rafiu +2 more
doaj +1 more source
Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad +22 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo +4 more
wiley +1 more source
Analysis Of Unreliable Multi-Server Queueing System With Breakdowns Spread And Quarantine
ECMS 2017 Proceedings edited by Zita Zoltay Paprika, Péter Horák, Kata Váradi, Péter Tamás Zwierczyk, Ágnes Vidovics-Dancs, János Péter Rádics, 2017 We consider an unreliable multi-server queue in which the rate of servers' breakdowns increases when the number of broken servers grows. To prevent quick degradation of the system, it is proposed to switch to a quarantine regime when the number of broken servers exceeds some threshold and to maintain this regime until the number of broken servers ...
Dudin A. +3 more
openaire +4 more sources
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar +2 more
wiley +1 more source