Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Analysis of an intergenerational service-learning experience based on physical exercise in a community setting: a mixed-method study. [PDF]
Alonso-Cortés Fradejas B +5 more
europepmc +1 more source
Implementing Service Learning in Pre-Service Teacher Coursework
S. Hildenbrand, Susan E. Schultz
semanticscholar +1 more source
Unveiling a Bulk WTaV Multicomponent Alloy With Superior Thermal Properties and Manufacturability
ABSTRACT Many tungsten (W)‐based medium and high entropy alloys (HEA) demonstrate superior microstructural stability and enhanced mechanical properties as compared to pure W, effectively rendering them as viable candidate materials for extreme environments such as nuclear fusion, aerospace applications, and so on.
Ishtiaque K. Robin +11 more
wiley +1 more source
Empowering the future: improving community wellbeing and health literacy through outreach and service-learning. [PDF]
Restini CBA +4 more
europepmc +1 more source
Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials
Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan +8 more
wiley +1 more source
Australian rural service learning student placements: a national survey. [PDF]
Moran M, Miles S, Martin P.
europepmc +1 more source
Forecasting Root Rot Disease through Predictive Microbial Functional Profiling
Predicting soil‐borne disease moves beyond observation with a framework that elevates microbial functional genes into reliable forecasting biomarkers. By coupling targeted qPCR assays for core stress‐response genes with machine learning, this method detects root rot risks in pre‐symptomatic soils with over 80% accuracy.
Chuan You +11 more
wiley +1 more source
The Impact of an Intergenerational Service Learning Program on Psychological Distress for Homebound Older Adults. [PDF]
Chan KT +6 more
europepmc +1 more source
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park +11 more
wiley +1 more source

