Results 51 to 60 of about 2,081,272 (296)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A novel quality of service-aware service composition method for cloud computing using enhanced Prairie Dog Metaheuristic Optimization Algorithm

Journal of Engineering and Applied Science
Efficient composition of cloud services under Quality of Service (QoS) constraints is a critical challenge in service-oriented computing. Traditional metaheuristic approaches often struggle to balance global exploration and SLA compliance in high ...
Dongge Tian
doaj   +1 more source

Pembuatan Service Level Requirement, Service Level Agreement dan Operational Level Agreement pada Layanan Help Desk SAP Berdasarkan Kerangka Kerja ITIL Versi 2011 (Studi Kasus : Pupuk Indonesia Holding Company) [PDF]

, 2016
PT. Pupuk Indonesia Holding Company baru saja melakukan implementasi SAP pada tahun 2014. Dalam penerapannya, Perusahaan merasa perlu membuat help desk SAP sebagai pusat penanganan masalah bagi Perusahaan dan 7 anak Perusahaannya yang kemudian dapat ...
Prameswari, N. S. (Nur), Susanto, T. D. (Tony)   +1 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Service-Level Agreements for Electronic Services [PDF]

IEEE Transactions on Software Engineering, 2010
The potential of communication networks and middleware to enable the composition of services across organizational boundaries remains incompletely realized. In this paper, we argue that this is in part due to outsourcing risks and describe the possible contribution of Service-Level Agreements (SLAs) to mitigating these risks.
Skene, James, Raimondi, Franco, Emmerich, Wolfgang   +2 more
openaire   +1 more source

Using Information Filtering in Web Data Mining Process [PDF]

, 2007
Web service-oriented Grid is becoming a standard for achieving loosely coupled distributed computing. Grid services could easily be specified with web-service based interfaces.
Bruza, Peter, Lau, Raymond, Li, Yuefeng, Wu, Shengtang, Xu, Yue, Zhou, Xujuan   +5 more
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

A comparison between e-government practices in Taiwan and New Zealand. [PDF]

, 2007
Few studies have focused on comparing the state of e-government in Western- and Non-Western settings, where the political, social, economic, and cultural environments can be markedly different.
Chen, Wan Jung, Deakins, Eric, Dillon, Stuart M.   +2 more
core   +1 more source

Extending WS-Agreement to Support Automated Conformity Check on Transport and Logistics Service Agreements [PDF]

, 2013
Checking whether the agreed service quality attributes are fulfilled or maintained during the service life-cycle is a very important task for SLA (Service Level Agreement) enforcement.
Cassales Marquezan, Clarissa, Gutiérrez, Antonio M., Metzger, Andreas, Pohl, Klaus, Resinas Arias de Reyna, Manuel, Ruiz Cortés, Antonio   +5 more
core   +1 more source