Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Randomized routing of virtual machines in IaaS data centers [PDF]
PeerJ Computer Science, 2019 Cloud computing technology has been a game changer in recent years. Cloud computing providers promise cost-effective and on-demand resource computing for their users.
Hadi Khani, Hamed Khanmirza
doaj +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Analysis of the causes and level of maintenance for enterprise systems in construction companies
Journal of Civil Engineering and Management, 2018 A construction company without a similar information technology (IT) system in the past has insufficient historical data to use for investment decision-making of IT system.
Chijoo Lee, Chiheyon Lee, Eul-Bum Lee
doaj +1 more source
An economic market for the brokering of time and budget guarantees [PDF]
, 2014 Grids offer best effort services to users. Service level agreements offer the opportunity to provide guarantees upon services offered, in such a way that it captures the users’ requirements, while also considering concerns of the service providers.
Altmann +28 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
SLA-Based Service Provisioning Optimization in Vehicular Cloud Networks Using Fuzzy Logic
IEEE AccessVehicular Cloud Networks (VCNs) enable vehicles to act as servers and share their abundant computing and storage resources. However, resource allocation in VCNs faces challenges due to factors like service pricing, resource variability, and mobility ...
Farhoud Jafari Kaleibar, Marc St-Hilaire
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
COLLABORATION MANAGEMENT FOR SUBJECTS OF EDUCATIONAL ACTIVITY IN INFORMATION-EDUCATIONAL SPACE
Открытое образование (Москва), 2016 This article presents a conception of collaboration of main actors in information-educational space, based on service level management process from the library of best practices ITIL, composition and procedure of information interchange between actors ...
Yury F. Telnov +2 more
doaj +1 more source
Improve oil company competitiveness by aligning company performance management with service strategy from well services company [PDF]
, 2014 Petroleum business is a highly risk business that requires high capital and high supporting technology.This business is highly depends to their business partner (well services company) support in providing excellent services to discover new field and to ...
Wiguna, Made Satria
core