Results 71 to 80 of about 2,081,272 (296)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Enforcing reputation constraints on business process workflows [PDF]

, 2014
The problem of trust in determining the flow of execution of business processes has been in the centre of research interst in the last decade as business processes become a de facto model of Internet-based commerce, particularly with the increasing ...
Aziz, Benjamin, Hamilton, Geoff
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

EVALUASI DAN PENINGKATAN KUALITAS SISTEM PELAYANAN CALL CENTER DENGAN PENDEKATAN LEAN SIX SIGMA (Studi Kasus pada Call Center 147 PT. TELKOM DIVRE IV JATENG-DIY) [PDF]

, 2006
ABSTRAKSI PT. Telekomunikasi Indonesia, Tbk (PT. TELKOM) merupakan perusahaan telekomunikasi terbesar di Indonesia. Call center bertanggung jawab atas pertanyaan dan komplain pelanggan terhadap produk yang dikeluarkan PT. TELKOM.
LAILY, CHAIRIL
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Probe on Service Level Agreement of Integrated Mine Wide Automation System

Gong-kuang zidonghua, 2011
In view of problems of jumbled service level and long service period of integrated mine wide automation system, the paper put forward a scheme of using service level agreement to classify and grade in-sale services and after-sale services, and introduced
CHEN Jian-wei, ZHU Jin-guang
doaj  

Challenges for Continuous, Provable Security Service Level Agreement Management in Computing Continuum

IEEE Access
Vertical industries start taking advantage of computing continuum by hosting their applications or using additional services offered by several Cloud Service Providers.
Krzysztof Bocianiak, Tomasz Pawlikowski, Aleksandra Podlasek, Jean-Philippe Wary, Jacek Wierzbowski   +4 more
doaj   +1 more source

A WS-Agreement Extension for Specifying Temporal Properties in SLAS [PDF]

, 2007
Service level agreements (SLA) in service oriented architectures allow to regulate the service trading from providers to consumers. So SLAs must describe the agreement properties in a precise manner.
Fernández Montes, Pablo, Martín Díaz, Octavio, Müller Cejás, Carlos, Resinas Arias de Reyna, Manuel, Ruiz Cortés, Antonio   +4 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Adaptive SLA management along value chains for service individualization [PDF]

, 2009
The object of our investigation is a software architecture for adaptive Service Level Agreement (SLA) management in value chains for service individualization.
Karaenke, Paul, Kirn, Stefan, Micsik, András   +2 more
core   +1 more source