Results 51 to 60 of about 11,676,712 (286)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Methodology for assessing the organizational system of service quality management

open access: yesИнтеллект. Инновации. Инвестиции
The relevance of the study is due to the need to improve the assessment and management of the quality of services in the field of tourism and hospitality, where the level of service determines the competitiveness of enterprises.
A. I. Lesnikov   +2 more
doaj   +1 more source

Fearless: Immersion Projects

open access: yes, 2013
Students on an Immersion Project in New Orleans are definitely doing some great work this week! The students spent part of the week working with Grow Dat Youth Farm in New Orleans City Park, an organization that hires youth from the city to work at the ...
Center for Public Service,
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Pengembangan olah pangan berbahan baku jagung dan talas bagi kelompok tani desa sungai enau kecamatan kuala mandor

open access: yesTeknologi Pangan: Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian, 2019
Taro and maize are agricultural products that have nutrients, especially fiber, so it is very good to be developed and its presence in the location of the activity is relatively abundant, so that further management is needed.
Desdy Hendra Gunawan, Ridwan Salim
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Service Systems and Service Innovation: Two Pillars of Service Science

open access: yesProcedia Computer Science, 2016
AbstractService science is perceived as a multidisciplinary approach with the service system as its most important element. The services we use are provided through a certain service system, whereas service system has a specific structure and creates value through defined interactions between its entities, as well as through interactions with external ...
Stoshikj, Marina   +2 more
openaire   +1 more source

Fearless: One Billion Rising

open access: yes, 2013
One Billion Rising is the annual global celebration associated with the kick-off of the Vagina Monologues. It is a day that encourages women to dance, taking ownership of their bodies, of the space they occupy, and of the rights to expression that they ...
Center for Public Service,
core  

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