Results 71 to 80 of about 2,315,510 (247)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Personal and Professional Readiness of Public Servants
Управленческое консультирование, 2018 In the article the system of formation of personal and professional readiness of public servants in modern conditions is considered. The author based on differentiation between objects of management in public administration and management postulates ...
Victor Leonidovich Cheplyaev
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Aktuelle Veröffentlichungen zum Themenfeld „Hochschule und Weiterbildung”
Zeitschrift Hochschule und Weiterbildung, 2021 Ein Service der Bibliothek des DIE
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Resource allocation improvement in the tasks of airport ground handling operations
Aviation, 2015 It is a global trend for the airport ground handling market to become liberalised. Fiercer competition lead to the necessity to improve efficiency and minimise costs. A mathematical model of optimal resource allocation by aircraft ground handling company
Kristina Marintseva +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Legal Classification of Employment Relations of State Bureau of Investigation Personnel
Bulletin of Kharkiv National University of Internal AffairsThe sectoral affiliation of employment relations concerning personnel of the State Bureau of Investigation (SBI) is examined. The scholarly contributions regarding the classification of service relations within law enforcement agencies are analyzed ...
D. Ye. Zherebtsov
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
International Journal of Circumpolar Health, 2017 Patients, relatives, healthcare workers and administrators are concerned about the quality of care offered. We aimed to explore the treatment of acute myocatrdial infarction (AMI) in Northern Norway, compare it with the national figures, and document ...
J. Norum +8 more
doaj +1 more source