Results 81 to 90 of about 11,863,905 (304)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Aktuelle Veröffentlichungen zum Themenfeld „Hochschule und Weiterbildung”

open access: yesZeitschrift Hochschule und Weiterbildung, 2021
Ein Service der Bibliothek des DIE
doaj   +1 more source

Treatment of acute myocardial infarction in the sub-arctic region of Norway. Do we offer an equal quality of care?

open access: yesInternational Journal of Circumpolar Health, 2017
Patients, relatives, healthcare workers and administrators are concerned about the quality of care offered. We aimed to explore the treatment of acute myocatrdial infarction (AMI) in Northern Norway, compare it with the national figures, and document ...
J. Norum   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Fearless: Immersion Projects

open access: yes, 2013
Students on an Immersion Project in New Orleans are definitely doing some great work this week! The students spent part of the week working with Grow Dat Youth Farm in New Orleans City Park, an organization that hires youth from the city to work at the ...
Center for Public Service,
core  

LEGAL FICTION OF SERVICE OF DOCUMENTS IN ADMINISTRATIVE PROCEEDINGS CARRIED OUT BY PUBLIC ORGANS

open access: yesZeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2014
The aim of the paper is to analyse legal fiction of service of correspondence in accordance with Code of Administrative Proceedings and Tax Law Act. The essence of serving pursuant to Article 44 of Code of Administrative Proceedings and Article 150 of ...
Dorota HAMERLAK, Magdalena DREWNIANY
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Service Clustering: Building Cohesive Public Service Capacity [PDF]

open access: yes, 2005
The human services support system of Allegheny County, Pennsylvania, incorporates a complex and concentrated network of services for its economically disadvantaged citizens.In 2004, the Allegheny County Department of Human Services (DHS) served 231,400 ...

core  

Exploring customer loyalty in the South African mobile telecommunications sector

open access: yesCogent Business & Management, 2017
The South African mobile telecommunications environment has become increasingly competitive, thus there is increased focus on acquiring and retaining loyal customers in order to facilitate repeat purchases, guarantee future revenues and shield the ...
Simon Morgan, Krishna Govender
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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