Results 101 to 110 of about 463,297 (313)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Agreement for Use of Images and Likenesses in Service Products

open access: yes, 2013
imagerelease.pdfU.S. Fish & Wildlife Service Agreement for Use of Images and Likenesses in Service Products Instructions A signed release is required from Non-Service subjects appearing and requiring identification in all photographs and videos taken by ...

core  

DIGITAL PERSONAL MENTORING AGREEMENT AS A TOOL FOR REGULATING INTERNET BLOGGERS’ EDUCATIONAL ACTIVITIES

open access: yesПравовое государство: теория и практика
The current Internet environment is almost unimaginable without bloggers – active social media participants who share content focused on particular topics on their pages, engaging a target audience (subscribers) to view and assess it.
KOLESNICHENKO Olga Viktorovna
doaj   +1 more source

До питання розмежування договорів підряду та договорів про надання послуг

open access: yesТеорія і практика правознавства, 2016
Досліджено правову природу договору підряду та договору про надання послуг. Встановлено ознаки, що дозволяють відмежувати вказані договори один від одного.
В. П. Янишен
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Do You E-Care? Analyzing the Impact of Conversational Agreement in Online Customer Service [PDF]

open access: yes, 2017
To assess online consumers’ service evaluations, many firms use automated sentiment analysis, yet this method does not capture dialogues dynamics between consumers and employees.
Grewal, Dhruv   +1 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Towards Collaborative Service Level Agreement Negotiation

open access: yes, 2007
A critical issue in the Service Level Agreement management for service composition is to control the relationship between the composite service and the component services in the negotiation. However, existing approaches are inefficient.
Yang, Yun   +4 more
core  

Enabling Service Level Agreement-Differentiated Protection in C+L Multiband Optical Networks

open access: yesIEEE Open Journal of the Communications Society
Band division multiplexing (BDM) is a promising technology to upgrade the capacity of elastic optical networks (EON). By using both C and L bands instead of just the C-band, networks can support a larger number of connections.
Soheil Hosseini   +5 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

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