Results 31 to 40 of about 8,255,341 (304)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Block A, County Hall, Taunton, Somerset. Historic Building Record (OASIS ID: bristolb1-398681)
, 2020 Between 2018 and 2020 Bristol & Bath Heritage Consultancy undertook a Level 3 Historic Building Record of Block A, County Hall, Taunton, Somerset. The Grade II listed Somerset County Council Offices were completed in 1935 in accordance with plans drawn ...
Simon Cox
core +1 more source
Measuring health systems strength and its impact: experiences from the African Health Initiative
BMC Health Services Research, 2017 Background Health systems are essential platforms for accessible, quality health services, and population health improvements. Global health initiatives have dramatically increased health resources; however, funding to strengthen health systems has not ...
Kenneth Sherr +6 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Modeling Building Block Interdependency
, 1998 The Building-Block Hypothesis appeals to the notion of problem decomposition and the assembly of solutions from sub-solutions. Accordingly, there have been many varieties of GA test problems with a structure based on building-blocks.
Pollack, Jordan B. +2 more
core +1 more source
Measurement Validation of Service Ethics Higher Education in Indonesia
Jurnal Dinamika Manajemen, 2019 This study aims to develop an ethics index of education services at universities in Indonesia with an approach to marketing education services. This is because service ethics is a long-term investment to build trust by providing services that can create ...
Erni Rusyani +2 more
doaj +1 more source
Building Blocks for Mapping Services
, 2013 Mapping services are ubiquitous on the Internet. These services enjoy a considerable user base. But it is often overlooked that providing a service on a global scale with virtually millions of users has been the playground of an oligopoly of a select few service providers are able to do so.
openaire +4 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Decision Support System for Blockage Management in Fire Service
Studies in Logic, Grammar and Rhetoric, 2014 In this article we present the foundations of a decision support system for blockage management in Fire Service. Blockage refers to the situation when all fire units are out and a new incident occurs.
Krasuski Adam, Kreński Karol
doaj +1 more source