Results 41 to 50 of about 8,255,341 (304)

Adaptive Height Optimization for Cellular-Connected UAVs: A Deep Reinforcement Learning Approach

IEEE Access, 2023
Providing reliable connectivity to cellular-connected Unmanned Aerial Vehicles (UAVs) can be very challenging; their performance highly depends on the nature of the surrounding environment, such as density and heights of the ground Base Stations (BSs ...
Erika Fonseca, Boris Galkin, Ramy Amer, Luiz A. DaSilva, Ivana Dusparic   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Electric Vehicle Fleets as Balancing Instrument in Micro-Grids

Energies, 2021
Micro-grids have become the building block of modern energy systems, where distributed resources are the characterizing feature. The charging operation of electric vehicles can be exploited as a flexible load to achieve operational goals of the micro ...
Giambattista Gruosso, Fredy Orlando Ruiz
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Redefining Electronic Health Records (EHR) and Electronic Medical Records (EMR) to Promote Patient Empowerment

IJID (International Journal on Informatics for Development), 2019
A successful healthcare organization exists when it provides good quality service. Powered by technological changes like big data, cloud computing, and Internet of Things, healthcare information is accessed and owned and the patient has become evolving ...
Muhammad Anshari
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Teaching in the block: perceptions from an agricultural education classroom [PDF]

, 2002
Plan BA relatively new initiative called block scheduling is being used in high schools all over the country. Several schools are investigating and adopting block schedules to replace traditional schedules.
Spoelstra, Elizabeth
core  

Soa-based guidelines for value-added service development on jain slee environments.

Revista Ingenierías Universidad de Medellín, 2014
The appropriation of the new technologies is a key aspect to maintain high competitiveness in a globalized economy for telecom carriers. The benefits providedby these new technologies allow them to easily adapt to the market conditions and to satisfy the
Julián Andrés Rojas Meléndez, Jesús David Ramírez, Juan Carlos Corrales   +2 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source