Results 51 to 60 of about 8,255,341 (304)

Studley Castle Hotel, Warwickshire: Level 4 Building Recording of 1938 Accommodation Block (headland3-263965)

, 2017
Headland Archaeology were commissioned to carry out a Historic Building Recording (HBR) survey of the 1938 wing of Studley Castle Hotel, near Studley in Warwickshire; as part of a wider archaeological mitigation strategy for the proposed re-development ...
Headland Archaeology Ltd
core   +1 more source

User-Centric Joint Beamforming for Multi-Antenna UAV Networks With 3D Blockage Effects

IEEE Access
In unmanned aerial vehicle (UAV) networks, introducing multiple-input/multiple-output (MIMO) technology brings promising capacity gains by exploiting spatial multiplexing.
Xianming Zhao, Yuting Zhu, Hongtao Zhang
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Investigating the Influence of Urban Morphology on Seasonal Thermal Environment Based on Urban Functional Zones

Land
With the rapid advancement of urbanization, urban heat environment issues have become increasingly severe, presenting significant challenges to sustainable urban development.
Meiling Zeng, Chunxia Liu, Yuechen Li, Bo He, Rongxiang Wang, Zihua Qian, Fang Wang, Qiao Huang, Peng Li, Bingrong Leng, Yunjing Huang   +10 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Consumers' Perspectives on National Health Insurance in South Africa: Using a Mobile Health Approach

JMIR mHealth and uHealth, 2014
BackgroundBuilding an equitable health system is a cornerstone of the World Health Organization (WHO) health system building block framework. Public participation in any such reform process facilitates successful implementation. South Africa has embarked
Weimann, Edda, Stuttaford, Maria C
doaj   +1 more source

Synergies or Trade-Offs? Optimizing a Virtual Urban Region to Foster Plant Species Richness, Climate Regulation, and Compactness Under Varying Landscape Composition

Frontiers in Environmental Science, 2020
Ongoing urbanization forces us to reflect on how we can cater for multiple targets when building cities. In this study, we investigate whether compactness as a common urban development strategy, climate regulation as an example for an ecosystem service ...
Nina Schwarz, Nina Schwarz, Falk Hoffmann, Sonja Knapp, Sonja Knapp, Michael Strauch   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Survey: National Parks Service, "Historic American Building Survey Inventory: Brown's Chapel," July 13, 1970

, 2007
Textual: survey; copy, 11" x 8.5" (29.7 cm x 21.6 cm)Survey from the National Parks Service entitled "Historic American Building Survey Inventory: Brown's Chapel" dated July 13, 1970.
National Parks Service
core   +1 more source