Results 61 to 70 of about 125,581 (263)
Towards Service Architectures in Service-oriented Computing
, 2010 Service-oriented architectures (SOA) are nowadays a widely promoted field of study in service-oriented computing (SOC) but unfortunately often discussed only in the light of enterprise IT solutions and the Web services technologies. By diving into the technical fundamentals of SOA we found a more general concept of service architectures; a concept that
Mäki, Matti, Pakkala, Daniel
openaire +2 more sources
Computer service for obstetric records. [PDF]
BMJ, 1971 info:eu-repo/semantics ...
openaire +3 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Service migration of heterogeneous cloud computing platform
物联网学报, 2020 With the rapid development of 5G communication technology,Internet+ and the Internet of things (IoT),cloud computing as an Internet-based virtual resource management and a distributed computing technology,provides services to users in a dynamic,on-demand
Feng WEI +5 more
doaj +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Cognitive Computing to Optimize IT Services [PDF]
2018 IEEE 17th International Conference on Cognitive Informatics & Cognitive Computing (ICCI*CC), 2018 In this paper, the challenges of maintaining a healthy IT operational environment have been addressed by proactively analyzing IT Service Desk tickets, customer satisfaction surveys, and social media data. A Cognitive solution goes beyond the traditional structured data analysis by deep analyses of both structured and unstructured text.
openaire +2 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Pre-service Teachers’ Perspectives on One-to-one Computing: A Mixed Method Study
EAI Endorsed Transactions on e-Learning, 2014 This study aims at exploring pre-service teachers’ perspectives on one-to-one (1:1) computing in teaching and learning. It gathered data regarding various aspects of 1:1 computing from 145 pre-service teachers at a public university in USA.
D. Xiao, W.F. Chen
doaj +1 more source