Results 61 to 70 of about 1,160,010 (271)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Robust hierarchical federated learning with dual-layer filtering mechanism

International Journal of Advanced Robotic Systems
Hierarchical federated learning (HFL) is an effective “cloud-edge-device” distributed model training framework that protects data privacy. During HFL training, poisoning attacks on local data and transmitted models can affect the accuracy of the global ...
Chaoyi Yang, Wei Liang, Yuxiang Chen, Jiahong Xiao, Dacheng He, Tianxiong Liu, Jin Wang, Amr Tolba   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A New Convolutional Neural Network-Based Steganalysis Method for Content-Adaptive Image Steganography in the Spatial Domain

IEEE Access, 2020
Convolutional neural network-based methods are attracting increasing attention in steganalysis. However, steganalysis for content-adaptive image steganography in the spatial domain is still a difficult problem.
Zhili Xiang, Jun Sang, Qian Zhang, Bin Cai, Xiaofeng Xia, Weiqun Wu   +5 more
doaj   +1 more source

Forum Session at the First International Conference on Service Oriented Computing (ICSOC03) [PDF]

, 2003
The First International Conference on Service Oriented Computing (ICSOC) was held in Trento, December 15-18, 2003. The focus of the conference ---Service Oriented Computing (SOC)--- is the new emerging paradigm for distributed computing and e-business ...
Aiello, Marco, Bussler, Chris, D'Andrea, Vincenzo, Yang, Jian   +3 more
core  

Efficient Redundancy Techniques for Latency Reduction in Cloud Systems

, 2017
In cloud computing systems, assigning a task to multiple servers and waiting for the earliest copy to finish is an effective method to combat the variability in response time of individual servers, and reduce latency.
Joshi, Gauri, Soljanin, Emina, Wornell, Gregory   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Computing as a service pattern based on edge computing

Dianzi Jishu Yingyong, 2019
Edge computing is a computational model for all terminal devices from cloud to edge path, which emerges in the era of interconnection of all things. The existing server pattern under cloud computing model cannot satisfy the application requirements of ...
Wang Tengfei, Zhang Ruiquan, Li Jianhong, Wang Long, Hou Linqing, Wang Zhongyang   +5 more
doaj   +1 more source

Optimal Pricing-Based Edge Computing Resource Management in Mobile Blockchain

, 2017
As the core issue of blockchain, the mining requires solving a proof-of-work puzzle, which is resource expensive to implement in mobile devices due to high computing power needed.
Feng, Shaohan, Han, Zhu, Niyato, Dusit, Wang, Ping, Xiong, Zehui   +4 more
core   +1 more source