Results 91 to 100 of about 239,231 (306)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Principles of personalisation of service discovery
, 2004 We define personalisation as the set of capabilities that enables a user or an organisation to customise their working environment to suit their specific needs, preferences and circumstances.
Terry Payne +14 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
IEEE AccessSocial IoT (SIoT) refers to socializing in the Internet of Things (IoT), where things generate social relationships. Due to the development of objects and issues such as delayed response, slow search, and composite service process, distributed object ...
Bahar Allakaram Tawfeeq +3 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Research on a Web Services Discovery Method Based on Virtual Social Network
Dianxin kexue, 2013 A Web services discovery method based on virtual social network was proposed, looking for services to meet user requirements from the mutual competition and collaboration service relationship.
Shanliang Pan, Qinjiao Mao, Lu Han
doaj
Re-discovering repository architecture: adding discovery as a key service [PDF]
, 2008 This article proposes an architecture for institutional repositories (IRs) which is more service oriented and distributed than the typical view of a repository as a monolithic software application.
Sefton, Peter
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Semantic Service Matching Middleware for Mobile Devices Discovering Grid Services
, 2008 The combination of mobile and Grid computing enables high performance Grid access through resource-limited mobile devices. Many challenges require to be addressed before vision of building the bridge between Grid and mobile computing field is realized ...
Guan, Tao +8 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source