Results 61 to 70 of about 239,231 (306)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Service discovery at scale: limitations of centralized models and decentralized alternatives

Adaptivni Sistemi Avtomatičnogo Upravlinnâ
The paper examines contemporary approaches to service discovery in distributed, service-oriented, and microservice systems. It presents a comprehensive survey and comparative analysis of widely used solutions, highlighting their key strengths and ...
А. Лавров, М. Литвиненко, О. Сирота, П. Родіонов, А. Гуменюк   +4 more
doaj   +1 more source

Semantic Registration and Discovery System of Subsystems and Services within an Interoperable Coordination Platform in Smart Cities

Sensors, 2016
Smart subsystems like traffic, Smart Homes, the Smart Grid, outdoor lighting, etc. are built in many urban areas, each with a set of services that are offered to citizens. These subsystems are managed by self-contained embedded systems.
Gregorio Rubio, José Fernán Martínez, David Gómez, Xin Li   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

TTL-Chord: A Chord-based Approach for Semantic Web Services Discovery [PDF]

, 2014
Recently, P2P-based discovery methods for semantic Web services require special attention from collaboration and interoperability in distributed computing environment.
Bounas, Mohamed Elhadi, Messelem, Youcef, Gharzouli, Mohamed   +2 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A Semantic Framework for Priority-based Service Matching in Pervasive Environments [PDF]

, 2007
The increasing popularity of personal wireless devices has raised new demands for the efficient discovery of heterogeneous devices and services in pervasive environments.
De Roure, David, Terry Payne, Lewis, T, Payne, Terry, Ayomi B, David De Roure, Roure, DD, Payne, TR, Ayomi Bandara, Tim Lewis, Bandara, Ayomi, Bandara, A, Lewis, Tim   +12 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Web service discovery method based on semantic expansion

Tongxin xuebao, 2007
A Web service discovery method based on semantic expansion was provided.It semantically expanded the conception of service description and service request.The semantic expansion way includes equivalent expansion,feature expansion and compose expansion.It
ZHANG Zheng, ZUO Chun, WANG Yu-guo
doaj  

Research on Web Service Composition Matching Framework [PDF]

Jisuanji gongcheng, 2017
Existing service discovery methods only consider atomic service or service composition,which cannot meet the increasing demands of users.Aiming at this problem,this paper proposes a new Web service matching framework based on model transformation.In the ...
ZHOU Bo,ZENG Yi,CHEN Hengxin,LIU Huijun,YANG Yanning
doaj   +1 more source