Results 31 to 40 of about 196,490 (256)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Service function chain construct algorithm based on reliability

Tongxin xuebao, 2019
With the continuous expansion of network size and content quantity,network operators often face the problem of data transmission interruption,thus how to improve the reliability of data transmission has become a research hotspot.Started with the huge ...
Julong LAN, Zijin JIN, Penghao SUN, Yiming JIANG, Yue WANG   +4 more
doaj   +2 more sources

Security-aware Service Function Chain Deployment Method Based on Deep ReinforcementLearning [PDF]

Jisuanji kexue
As a key technology to improve the utilization of network resources,service function chain combined with deep reinforcement learning makes it possible to achieve flexible and secure deployment.However,how to effectively deploy service function chains ...
ZHU Ziyi, ZHANG Jianhui, ZENG Junjieand ZHANG Hongyuan
doaj   +1 more source

Resource Requirements for Reliable Service Function Chaining [PDF]

2018 IEEE International Conference on Communications (ICC), 2018
In the context of Software-Defined Networks (SDN), Network Function Virtualization (NFV) is a new network paradigm in which network functions are implemented in software as Virtual Network Functions (VNFs). To meet the demand, VNFs are next interconnected to form different complete end-to-end services, also known as a Service Function Chains (SFCs). We
Tomassilli, Andrea, Huin, Nicolas, Giroire, Frédéric, Jaumard, Brigitte   +3 more
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A Scalable Algorithm for the Placement of Service Function Chains [PDF]

IEEE Transactions on Network and Service Management, 2016
Network function virtualization (NFV) decouples software implementations of network functions from their hosts (or hardware). NFV exposes a new set of entities, the virtualized network functions (VNFs). The VNFs can be chained with other VNFs and physical network functions to realize network services.
Marouen Mechtri, Chaima Ghribi, Djamal Zeghlache   +2 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Service function chain deployment algorithm based on optimal weighted graph matching

Tongxin xuebao, 2019
Service function chain can support flexible network service requirement by linking virtual network functions.Aiming at the problem of service function chain deployment in a resource-constrained network,an algorithm for service function chain deployment ...
Dan LI, Julong LAN, Peng WANG, Yuxiang HU   +3 more
doaj   +2 more sources