Results 51 to 60 of about 196,490 (256)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Position-aware packet loss optimization on service function chain placement

Digital Communications and Networks
The advent of Network Function Virtualization (NFV) and Service Function Chains (SFCs) unleashes the power of dynamic creation of network services using Virtual Network Functions (VNFs).
Wenjie Liang, Chengxiang Li, Lin Cui, Fung Po Tso   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Reliable Service Function Chain Deployment Algorithm Based on Edge-Cloud Collaboration [PDF]

Jisuanji gongcheng
In response to the challenges of diverse requests and massive data in the Internet of Vehicle (IoV), the edge-cloud collaboration architecture supported by Software Defined Networking (SDN) and Network Function Virtualization (NFV) technologies has ...
SONG Yanrui, ZHUANG Lei, XU Zexi, FENG Xu, MO Wenshuai
doaj   +1 more source

ParaGraph: Subgraph-Level Network Function Composition With Delay Balanced Parallelism

IEEE Access, 2020
Recent efforts in the network function virtualization (NFV) field have targeted ameliorating end-to-end latency of service function chains (SFCs) using network function (NF) composition.
Dian Shen, Haoyang Liu, Rui Wang, Fang Dong, Fucun Li   +4 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Attack Graph-assisted Deep Reinforcement Learning-based Service Function Chain AttackRecovery Method [PDF]

Jisuanji kexue
SFC can provide customized services for the six scenarios of 6G with the advantages of on-demand orchestration,flexible networking,and other benefits,and 6G networks also put forward higher requirements for SFC.Resilience is receiving attention for the ...
ZHOU Deqiang, JI Xinsheng, YOU Wei, QIU Hang , YANG Jie
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

A satellite SFCs reliability protection method [PDF]

Zhihui kongzhi yu fangzhen
This paper discusses the reliability deployment of Service Function Chain (SFC) on the hybrid satellite network based on SDN architecture. Firstly, this paper describes the reliability protection problem of SFC, establishes the underlying network and SFC
WANG Zhong, WU Yang, SONG Huayu, LI Feilong
doaj   +1 more source