Results 41 to 50 of about 208,734 (256)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Improved grey wolf optimization algorithm based service function chain mapping algorithm

Dianxin kexue, 2022
With the rise of new Internet applications such as the industrial Internet, the Internet of vehicles, and the metaverse, the network’s requirements for low latency, reliability, security, and certainty are facing severe challenges.In the process of ...
Yue ZHANG, Junnan ZHANG, Xiaochun WU, Chen HONG, Jingjing ZHOU   +4 more
doaj   +2 more sources

Online Parallelized Service Function Chain Orchestration in Data Center Networks

IEEE Access, 2019
In recent years, much attention has been focused on deploying service function chains (SFCs), each of which is composed of a set of virtual network functions (VNFs) in a specified order.
Gang Sun, Zhenrong Chen, Hongfang Yu, Xiaojiang Du, Mohsen Guizani   +4 more
doaj   +1 more source

Service Chain Deployment Strategy Based on Quality of Service and Resource Constraints [PDF]

Jisuanji gongcheng, 2019
The Network Function Virtualization(NFV) makes the traditional network function deployed in the general server in the form of the software,and the network operator establishes the service function chain according to the service request,providing service ...
HAI Meisheng,YI Peng,JIANG Yiming
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Position-aware packet loss optimization on service function chain placement

Digital Communications and Networks
The advent of Network Function Virtualization (NFV) and Service Function Chains (SFCs) unleashes the power of dynamic creation of network services using Virtual Network Functions (VNFs).
Wenjie Liang, Chengxiang Li, Lin Cui, Fung Po Tso   +3 more
doaj   +1 more source

Reliable Service Function Chain Deployment Algorithm Based on Edge-Cloud Collaboration [PDF]

Jisuanji gongcheng
In response to the challenges of diverse requests and massive data in the Internet of Vehicle (IoV), the edge-cloud collaboration architecture supported by Software Defined Networking (SDN) and Network Function Virtualization (NFV) technologies has ...
SONG Yanrui, ZHUANG Lei, XU Zexi, FENG Xu, MO Wenshuai
doaj   +1 more source