Results 41 to 50 of about 196,490 (256)

Service Chain Deployment Strategy Based on Quality of Service and Resource Constraints [PDF]

open access: yesJisuanji gongcheng, 2019
The Network Function Virtualization(NFV) makes the traditional network function deployed in the general server in the form of the software,and the network operator establishes the service function chain according to the service request,providing service ...
HAI Meisheng,YI Peng,JIANG Yiming
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Improved grey wolf optimization algorithm based service function chain mapping algorithm

open access: yesDianxin kexue, 2022
With the rise of new Internet applications such as the industrial Internet, the Internet of vehicles, and the metaverse, the network’s requirements for low latency, reliability, security, and certainty are facing severe challenges.In the process of ...
Yue ZHANG   +4 more
doaj   +2 more sources

Online Parallelized Service Function Chain Orchestration in Data Center Networks

open access: yesIEEE Access, 2019
In recent years, much attention has been focused on deploying service function chains (SFCs), each of which is composed of a set of virtual network functions (VNFs) in a specified order.
Gang Sun   +4 more
doaj   +1 more source

Optimal Service Function Chain Composition in Network Functions Virtualization [PDF]

open access: yes, 2017
AbstractNetwork Functions Virtualization (NFV) is an emerging initiative where virtualization is used to consolidate Network Functions (NFs) onto high volume servers (HVS), switches, and storage. In addition, NFV provides flexibility as Virtual Network Functions (VNFs) can be moved to different locations in the network.
Andrés F. Ocampo   +8 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Availability and Reliability of Service Function Chain: A Quantitative Evaluation View

open access: yesInternational Journal of Computational Intelligence Systems, 2023
Service function chain (SFC) based on network function virtualization (NFV) technology can handle network traffic flexibly and efficiently. The virtual network function (VNF), as the core function unit of SFC, can experience software aging, which reduces
Yaru Li   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

OpenRASE: Service Function Chain Emulation

open access: yes2025 International Conference on Software, Telecommunications and Computer Networks (SoftCOM)
Service Function Chains (SFCs) are one of the key enablers in providing programmable computer networks, paving the way for network autonomy. However, this also introduces new challenges, such as resource allocation and optimisation related to their operation, requiring new algorithms to address these challenges.
Theviyanthan Krishnamohan   +1 more
openaire   +3 more sources

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