Results 61 to 70 of about 1,018,999 (294)

Impact of Processing-Resource Sharing on the Placement of Chained Virtual Network Functions

open access: yes, 2019
Network Function Virtualization (NFV) provides higher flexibility for network operators and reduces the complexity in network service deployment. Using NFV, Virtual Network Functions (VNF) can be located in various network nodes and chained together in a
Savi, Marco   +2 more
core   +1 more source

Penalty and reward contracts between a manufacturer and its logistics service provider [PDF]

open access: yes, 2016
Contracts are used to coordinate disparate but interdependent members of the supply chain. Conflicting objectives of these members and lack of coordination among the members lead to inefficiencies in matching supply with demand.
Aktas, Emel, Ulengin, Fusun
core   +4 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Online Parallelized Service Function Chain Orchestration in Data Center Networks

open access: yesIEEE Access, 2019
In recent years, much attention has been focused on deploying service function chains (SFCs), each of which is composed of a set of virtual network functions (VNFs) in a specified order.
Gang Sun   +4 more
doaj   +1 more source

Traffic Steering for Service Function Chaining [PDF]

open access: yesIEEE Communications Surveys & Tutorials, 2019
Dynamic service function chaining (SFC) is a technique that facilitates the enforcement of advanced services and differentiated traffic forwarding policies. It dynamically steers the traffic through an ordered list of service functions. Enabling SFC capabilities in the context of a software defined networking (SDN) architecture is promising, as it ...
Hantouti, Hajar   +4 more
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Energy-Efficient Service Function Chain Provisioning [PDF]

open access: yesElectronic Notes in Discrete Mathematics, 2018
Network Function Virtualization (NFV) is a promising network architecture concept to reduce operational costs. In legacy networks, network functions, such as firewall or TCP optimization, are performed by specific hardware. In networks enabling NFV coupled with the Software Defined Network (SDN) paradigm, network functions can be implemented ...
Huin, Nicolas   +3 more
openaire   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

ParaGraph: Subgraph-Level Network Function Composition With Delay Balanced Parallelism

open access: yesIEEE Access, 2020
Recent efforts in the network function virtualization (NFV) field have targeted ameliorating end-to-end latency of service function chains (SFCs) using network function (NF) composition.
Dian Shen   +4 more
doaj   +1 more source

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