Results 61 to 70 of about 26,223 (284)
Security-Aware Service Function Chaining and Embedding With Asymmetric Dedicated Protection
IEEE AccessIn the 5G and beyond 5G networks, achieving security-aware data transmission needs to convert clients ’ requests into a service function chain (SFC), each service function (SF) providing a certain security guarantee.
Ben Wang +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Service Chain (SC) Mapping with Multiple SC Instances in a Wide Area Network
, 2017 Network Function Virtualization (NFV) aims to simplify deployment of network services by running Virtual Network Functions (VNFs) on commercial off-the-shelf servers.
Gupta, Abhishek +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Optimal Service Function Chain Composition in Network Functions Virtualization [PDF]
, 2017 AbstractNetwork Functions Virtualization (NFV) is an emerging initiative where virtualization is used to consolidate Network Functions (NFs) onto high volume servers (HVS), switches, and storage. In addition, NFV provides flexibility as Virtual Network Functions (VNFs) can be moved to different locations in the network.
Andrés F. Ocampo +8 more
openaire +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
OpenRASE: Service Function Chain Emulation
2025 International Conference on Software, Telecommunications and Computer Networks (SoftCOM)Service Function Chains (SFCs) are one of the key enablers in providing programmable computer networks, paving the way for network autonomy. However, this also introduces new challenges, such as resource allocation and optimisation related to their operation, requiring new algorithms to address these challenges.
Theviyanthan Krishnamohan, Paul Harvey
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source