Results 61 to 70 of about 11,069,622 (290)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Trip chaining: Who wins who loses? [PDF]

This paper studies how trip chaining (combining commuting and shopping or commuting and child care) affects market competition: in particular, pricing and the equilibrium number of firms as well as welfare.
André De Palma, Fay Dunkerley, Stef Proost   +2 more
core   +4 more sources

Security-Aware Service Function Chaining and Embedding With Asymmetric Dedicated Protection

IEEE Access
In the 5G and beyond 5G networks, achieving security-aware data transmission needs to convert clients ’ requests into a service function chain (SFC), each service function (SF) providing a certain security guarantee.
Ben Wang, Jun Li, Shaohua Cao, Evrim Guler, Danyang Zheng   +4 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Performance Analysis of Docker-based NFV Service Chaining Networks in a Single-Host Environment

Sistemasi: Jurnal Sistem Informasi
Network Function Virtualization (NFV) and Service Function Chaining (SFC) enable network functions to be deployed as Virtual Network Functions (VNFs) on flexible commodity servers.
Rayhan Ziqrul Fitroh, Ichwan Nul Ichsan
doaj   +1 more source

Dynamic service function chain placement with instance reuse in Fog–Cloud​ Computing

ICT Express, 2023
The advent of Network Function Virtualization (NFV) technology has brought flexible provisioning to Fog–Cloud Computing-based Networks (FCCNs) for enterprises to outsource their network functions to data center networks.
Xueqiang Li, Cai Su, Mostafa Ghobaei-Arani, Mustafa Fahem Albaghdadi   +3 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

VNF Service Chaining in Optical Data Center Networks

, 2017
Virtualized network function (VNF) service chaining in optical datacenter networks (DCN) is a more complex problem than that in packet-switched networks, as it introduces additional constraints related to the optical network.
Ahmad Rostami, Gross, James,, James Gross, Nikam, Vikrant, Rostami, Ahmad, Gross, James, Vikrant Nikam, Nikam, Vikrant,   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source