Results 81 to 90 of about 11,069,622 (290)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

NFV and VNF Service Chaining on SAVI SDI [PDF]

open access: yes, 2016
Network Function Virtualization, a flexible networking architecture virtualizing network nodes, allows modular development of network functionalities and quick deployment on cloud infrastructures.
Yasrebi, Seyed Pouya
core   +1 more source

Service Function Chaining in 5G & Beyond Networks : Challenges and Open Research Issues

open access: yes, 2020
| openaire: EC/H2020/871780/EU//MonB5GService Function Chaining (SFC) is a trending paradigm, which has helped to introduce unseen flexibility in telecom networks.
Hantouti, Hajar   +2 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Intent-based Service Function Chaining on ETSI NFV Platforms

open access: yes, 2019
The emerging network paradigms allow service providers to completely rethink the way network services are designed, developed, provisioned, and managed.
Walter Cerroni   +7 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

open access: yesFEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer   +7 more
wiley   +1 more source

On scalable service function chaining with O(1) flowtable entries [PDF]

open access: yes, 2018
The emergence of Network Function Virtualization (NFV) enables flexible and agile service function chaining in a Software Defined Network (SDN). While this virtualization technology efficiently offers customization capability, it however comes with a ...
Ren, Yi   +3 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

open access: yesFEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki   +5 more
wiley   +1 more source

Optimal Execution of Virtualized Network Functions for Applications in Cyber-Physical-Social-Systems

open access: yesIEEE Access, 2018
Cyber-physical-social systems exploit the relationship between humans, computers, and the physical environment to provide high-quality real-time and personalized services.
Rofiqul Islam   +5 more
doaj   +1 more source

Optimal Service Function Chain Composition in Network Functions Virtualization [PDF]

open access: yes, 2017
AbstractNetwork Functions Virtualization (NFV) is an emerging initiative where virtualization is used to consolidate Network Functions (NFs) onto high volume servers (HVS), switches, and storage. In addition, NFV provides flexibility as Virtual Network Functions (VNFs) can be moved to different locations in the network.
Andrés F. Ocampo   +8 more
openaire   +3 more sources

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