Results 71 to 80 of about 2,331 (295)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Intent-based Service Function Chaining on ETSI NFV Platforms
, 2019 The emerging network paradigms allow service providers to completely rethink the way network services are designed, developed, provisioned, and managed.
Walter Cerroni +7 more
core +1 more source
, 2020 With the advent of Network Function Virtualization (NFV) techniques, a subset of the Internet traffic will be treated by a chain of virtual network functions (VNFs) during their journeys while the rest of the background traffic will still be carried ...
Ning, Zili +5 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Orchestrating service function chaining in cloud environments
, 2022 532538The rapid emergence of Software Defined Networks (SDN) and Network Function Virtualization (NFV) concepts is enabling the innovation of cloud infrastructures for supporting real time services and applications. Interconnecting Service Functions (SFs)
Medhat, Ahmed M. +4 more
core
Optimal Execution of Virtualized Network Functions for Applications in Cyber-Physical-Social-Systems
IEEE Access, 2018 Cyber-physical-social systems exploit the relationship between humans, computers, and the physical environment to provide high-quality real-time and personalized services.
Rofiqul Islam +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Demo: Software-Defined Network Service Chaining
, 2014 Network Function Virtualization is a promising approach for network operators to allow moving network functions from hardware appliances to a pure software-based solution.
Hausheer, David +9 more
core +1 more source
Genetic Algorithm for Holistic VNF-Mapping and Virtual Topology Design
IEEE Access, 2020 Next generation of Internet of Things (IoT) services imposes stringent requirements to the future networks that current ones cannot fulfill. 5G is a technology born to give response to those requirements. However, the deployment of 5G is also accompanied
Lidia Ruiz +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source