Results 111 to 120 of about 620,091 (310)

Performans Reproduksi Sapi Peranakan Simmental (Psm) Hasil Inseminasi Buatan di Kabupaten Sukoharjo Jawa Tengah

open access: yesJurnal Ilmiah Ilmu-Ilmu Peternakan, 2008
Information of performance reproduction crossed result of cow in ranch was immeasurable enough because  condition  of  its  different  conservancy.  This  research  aimed to  know  difference  of reproduction performances of  Simmental Crossed Cow (PSM)
Iswoyo Iswoyo, Priyantini Widiyaningrum
doaj   +3 more sources

Towards Industrialized Conception and Production of Serious Games [PDF]

open access: yes, 2009
Serious Games (SGs) have experienced a tremendous outburst these last years. Video game companies have been producing fun, user-friendly SGs, but their educational value has yet to be proven.
George, Sébastien   +4 more
core   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

REPRODUCTIVE PERFORMANCE OF RED SINDHI CATTLE UNDER HOT AND HUMID ENVIRONMENT OF BALOCHIST AN PROVINCE OF PAKISTAN

open access: yesPakistan Veterinary Journal, 2003
The present study was conducted to investigate the reproductive performance of 179 Red Sindhi cows with 485 lactation records covering 19 years period from 1978 to 1997, kept at the Government Red Sindhi Cattle Farm, Hub Chowki, District Lasbela ...
M. I. Mustafa, M Latif, M. K. Bashir1 and B. Ahmad
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Putting Gross National Happiness in the Service of Good Development [PDF]

open access: yes, 2003
Gross National Happiness (GNH) has only recently appeared on the international stage, yet it was immediately met with sympathy by scholars, political activists, and politicians around the world.
Hirata, Johannes
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Age of First Calving and Subsequent Fertility and Survival in Holstein Friesian Cattle

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
The aim of the study was to investigate the relationship between age at first calving (AFC) and subsequent fertility and survival up to third calving in Holstein Friesian heifers.
Constantin Găvan   +2 more
doaj  

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