Results 91 to 100 of about 9,333,014 (316)

Arts and Economic Prosperity 5: The Economic Impact of Nonprofit Arts & Cultural Organizations & their Audiences in Western New York [PDF]

, 2017
[Excerpt] Arts & Economic Prosperity 5 provides evidence that the nonprofit arts and culture sector is a significant industry in Western New York—one that generates $352.1 million in total economic activity.
Arts Services Initiative of WNY
core   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Can we plan services for children in foster care? Or do we just have to cope with what comes through the door?

Social Work and Society, 2017
To what extent is it possible to plan ahead for children coming into care? How can we ensure that there are enough foster homes available for new entrants and that the range of facilities is sufficiently wide to meet all of their different needs?
Roger Bullock
doaj  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

A New Paradigm of Software Service Engineering in the Era of Big Data and Big Service [PDF]

arXiv, 2016
Servitization is one of the most significant trends that reshapes the information world and society in recent years. The requirement of collecting,storing, processing, and sharing of the Big Data has led to massive software resources being developed and made accessible as web-based services to facilitate such process. These services that handle the Big
arxiv  

Spatially resolved monthly riverine fluxes of oxidised nitrogen (nitrate and nitrite) to the European shelf seas, 1960-2005 [PDF]

, 2007
This report documents the methodology developed for statistically modelling the spatial and temporal patterns of oxidised nitrogen (nitrate plus nitrite) riverine fluxes into the coastal waters of northwestern Europe, over the period 1960-2005.
Fisheries Research Services (Funder), Heath, M.   +1 more
core  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

INFLUENCE OF SERVICE QUALITY TO CUSTOMER SATISFACTION PT. POS INDONESIA KARAWANG BRANCH

Manajemen dan Bisnis, 2019
PT Pos Indonesia is still less demanded by society so that the number of deliveries by PT POS Indonesia every year Indonesia is unstable. The problem in this research is to know the effect of quality of services on customer satisfaction PT Pos Indonesia.
Asep Maulana, Evi Pebriyanti, Evi Depiana, Eriena Eka Wardani, Elfa Alfiani, Dwino Ayenero   +5 more
doaj   +1 more source

FASS: A Fairness-Aware Approach for Concurrent Service Selection with Constraints [PDF]

arXiv, 2019
The increasing momentum of service-oriented architecture has led to the emergence of divergent delivered services, where service selection is meritedly required to obtain the target service fulfilling the requirements from both users and service providers.
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source