Results 81 to 90 of about 6,280,398 (285)

Sistem Informasi Perhotelan Front Office Menggunakan Metode OOAD untuk Meningkatkan Pelayanan Customer: Studi Kasus Perhotelan-Open Source

ComTech, 2013
Technology plays an important role in various enterprise business processes for improved customer service, decision making, and means of information exchange.
Lianawati Christian, Angelina Permatasari, Lianna Sugandi   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Development of Scales for Measuring Specific Elements of the Services Marketing Mix

Ekonomski Vjesnik, 2009
The purpose of this research was to develop scales that might be used for measuring specific elements of services marketing mix, including service delivery process, physical environment, and employees. Psychometric characteristics of initial set of items
Edo Rajh
doaj  

Economic impacts of caring for autistic children in Ontario, Canada: report from a pilot study

Frontiers in Public Health
IntroductionAlthough research on the economic costs of autism is growing, relatively few studies have examined these costs incurred by families of autistic children in Canada.MethodsThis study designed and piloted a survey to capture the broader economic
Jingjing Xu, Gemma Graziosi, Felipe F. Rodrigues, Felipe F. Rodrigues, Renfang Tian, Rachel Birnbaum, Nicole Neil   +6 more
doaj   +1 more source

Sistem Pelayanan Jasa dan Penjualan Produk Percetakan Berbasis Web pada Proposter Indonesia

ComTech, 2011
Various constraints related to the availability of up-to-date information services and product sales happen to ProPoster Indonesia, a business of digital printing and display services system run since 2002.
Elidjen Elidjen, Gandi Cahyadi, Mario Andika   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

False Promise: World Heritage, Ecotourism, and the Local Community of Strahan, Tasmania

Heritage
The inscription of properties on the World Heritage List often places restrictions on existing livelihoods. In these contexts, tourism is widely held to be a panacea for the economic and social wellbeing of local communities.
Celmara Pocock, David Collett, Joan Knowles   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source